Nutrition is the most important environmental factor that can influence early developmental
processes through regulation of epigenetic mechanisms during pregnancy and neonatal …

Motivation: Bisulfite sequencing is currently the gold standard to obtain genome-wide DNA
methylation profiles in eukaryotes. In contrast to the rapid development of appropriate pre …

The hepatic stellate cells in the liver are stimulated sustainably by chronic injury of the
hepatocytes, activating myofibroblasts, which produce abundant collagen. Myofibroblasts …

DNA methylation is a major epigenetic modification that is strongly involved in the
physiological control of genome expression. DNA methylation patterns are largely modified …

In Europe, neuropsychiatric diseases currently make up approximately a third of the total
burden of disease. In 2004, 27% of the overall population was affected by at least one of the …

Type 2 diabetes (T2D) is a disorder of complex genetics influenced by interactions between
susceptible genetic loci and environmental perturbations. Intrauterine growth retardation is …

The prevalence of diabetes and its related complications are increasing significantly
globally. Collected evidence suggested that several genetic and environmental factors …

Most human phenotypes are influenced by a combination of genomic and environmental
factors. Engaging in regular physical exercise prevents many chronic diseases, decreases …

While cultured embryonic stem (ES) cells can be harvested in abundance and appear to be
the most versatile of cells for regenerative medicine, adult stem cells also hold promise, but …

Background Abnormal germline DNA methylation in males has been proposed as a
possible mechanism compromising spermatogenesis of some men currently diagnosed with …