Epigenetic regulation in human cancer: the potential role of epi-drug in cancer therapy
Epigenetics is dynamic and heritable modifications to the genome that occur independently
of DNA sequence. It requires interactions cohesively with various enzymes and other …
of DNA sequence. It requires interactions cohesively with various enzymes and other …
[HTML][HTML] Tissue invasion and metastasis: Molecular, biological and clinical perspectives
WG Jiang, AJ Sanders, M Katoh, H Ungefroren… - Seminars in cancer …, 2015 - Elsevier
Cancer is a key health issue across the world, causing substantial patient morbidity and
mortality. Patient prognosis is tightly linked with metastatic dissemination of the disease to …
mortality. Patient prognosis is tightly linked with metastatic dissemination of the disease to …
Epigenetic responses and the developmental origins of health and disease
D Goyal, SW Limesand, R Goyal - Journal of Endocrinology, 2019 - joe.bioscientifica.com
Maternal and paternal factors influence offspring development and program its genome for
successful postnatal life. Based on the stressors during gestation, the pregnant female …
successful postnatal life. Based on the stressors during gestation, the pregnant female …
Epigenetic switch drives the conversion of fibroblasts into proinvasive cancer-associated fibroblasts
Carcinoma-associated fibroblasts (CAF) mediate the onset of a proinvasive tumour
microenvironment. The proinflammatory cytokine LIF reprograms fibroblasts into a …
microenvironment. The proinflammatory cytokine LIF reprograms fibroblasts into a …
[HTML][HTML] Identification of polymorphic and off-target probe binding sites on the Illumina Infinium MethylationEPIC BeadChip
Genome-wide analysis of DNA methylation has now become a relatively inexpensive
technique thanks to array-based methylation profiling technologies. The recently developed …
technique thanks to array-based methylation profiling technologies. The recently developed …
DNA methylation: superior or subordinate in the epigenetic hierarchy?
B Jin, Y Li, KD Robertson - Genes & cancer, 2011 - journals.sagepub.com
Epigenetic modifications are heritable changes in gene expression not encoded by the DNA
sequence. In the past decade, great strides have been made in characterizing epigenetic …
sequence. In the past decade, great strides have been made in characterizing epigenetic …
Maternal high-fat diet alters methylation and gene expression of dopamine and opioid-related genes
Z Vucetic, J Kimmel, K Totoki, E Hollenbeck… - …, 2010 - academic.oup.com
Maternal obesity during pregnancy increases the risk of obesity in the offspring. Obesity,
arising from an imbalance of energy intake and expenditure, can be driven by the ingestion …
arising from an imbalance of energy intake and expenditure, can be driven by the ingestion …
Novel diagnostic DNA methylation episignatures expand and refine the epigenetic landscapes of Mendelian disorders
MA Levy, H McConkey, J Kerkhof… - Human Genetics and …, 2022 - cell.com
Overlapping clinical phenotypes and an expanding breadth and complexity of genomic
associations are a growing challenge in the diagnosis and clinical management of …
associations are a growing challenge in the diagnosis and clinical management of …
A twin approach to unraveling epigenetics
JT Bell, TD Spector - Trends in Genetics, 2011 - cell.com
The regulation of gene expression plays a pivotal role in complex phenotypes, and
epigenetic mechanisms such as DNA methylation are essential to this process. The …
epigenetic mechanisms such as DNA methylation are essential to this process. The …
DNA methylation in nonalcoholic fatty liver disease
J Hyun, Y Jung - International journal of molecular sciences, 2020 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD) is a widespread hepatic disorder in the United
States and other Westernized countries. Nonalcoholic steatohepatitis (NASH), an advanced …
States and other Westernized countries. Nonalcoholic steatohepatitis (NASH), an advanced …