Inhibition studies of soybean (Glycine max) urease with heavy metals, sodium salts of mineral acids, boric acid, and boronic acids
S Kumar, AM Kayastha - Journal of Enzyme Inhibition and …, 2010 - Taylor & Francis
Various inhibitors were tested for their inhibitory effects on soybean urease. The K i values
for boric acid, 4-bromophenylboronic acid, butylboronic acid, and phenylboronic acid were …
for boric acid, 4-bromophenylboronic acid, butylboronic acid, and phenylboronic acid were …
Design, synthesis, and urease inhibition studies of a series of 4-amino-5-aryl-3H-1,2,4-triazole-3-thiones
Abstract A series of 4-amino-5-aryl-3 H-1, 2, 4-triazole-3-thiones was synthesized by
reaction of aryl hydrazides with CS 2 and hydrazine hydrate. The synthesized compounds …
reaction of aryl hydrazides with CS 2 and hydrazine hydrate. The synthesized compounds …
Synthesis, structure and urease inhibition studies of Schiff base copper (II) complexes with planar four-coordinate copper (II) centers
X Dong, T Guo, Y Li, Y Cui, Q Wang - Journal of inorganic biochemistry, 2013 - Elsevier
Seven new Schiff base copper (II) complexes with planar four-coordinate copper (II) centers
have been synthesized and structurally characterized. The solid state structures of …
have been synthesized and structurally characterized. The solid state structures of …
Potent covalent inhibitors of bacterial urease identified by activity-reactivity profiling
K Macegoniuk, R Kowalczyk, A Rudzińska… - Bioorganic & Medicinal …, 2017 - Elsevier
Covalent enzyme inhibitors constitute a highly important group of biologically active
compounds, with numerous drugs available on the market. Although the discovery of …
compounds, with numerous drugs available on the market. Although the discovery of …
Synthesis, Biological Evaluation and Molecular Docking of Deferasirox and Substituted 1, 2, 4‐Triazole Derivatives as Novel Potent Urease Inhibitors: Proposing …
R Salehi Ashani, H Azizian… - Chemistry & …, 2020 - Wiley Online Library
A series of new deferasirox derivatives were synthesized through the reaction of
monosubstituted hydrazides with 2‐(2‐hydroxyphenyl)‐4H‐benzo [e][1, 3] oxazin‐4‐one …
monosubstituted hydrazides with 2‐(2‐hydroxyphenyl)‐4H‐benzo [e][1, 3] oxazin‐4‐one …
Urease
RP Hausinger, RP Hausinger - Biochemistry of nickel, 1993 - Springer
Urease catalyzes the hydrolysis of urea to yield ammonia and carbamate, which
spontaneously decomposes to form carbonic acid and a second molecule of ammonia …
spontaneously decomposes to form carbonic acid and a second molecule of ammonia …
Why urease is a di-nickel enzyme whereas the CcrA β-lactamase is a di-zinc enzyme
CE Valdez, AN Alexandrova - The Journal of Physical Chemistry …, 2012 - ACS Publications
Ureases and metallo-β-lactamases are amide hydrolases closely related in function and
structure. However, one major difference between them is that the former uses two nickel …
structure. However, one major difference between them is that the former uses two nickel …
Hydrolytically active tetranuclear [Ni II 2] 2 complexes: synthesis, structure, spectroscopy and phosphoester hydrolysis
GC Giri, A Patra, G Vijaykumar, L Carrella, M Bera - RSC Advances, 2015 - pubs.rsc.org
Three tetranuclear nickel (II) complexes,[Ni4 (H2chdp) 2 (H2O) 4] Br2· 4CH3OH· 3H2O
(1),[Ni4 (H2chdp) 2 (H2O) 4](PF6) 2 (2) and [Ni4 (H2chdp) 2 (H2O) 4](ClO4) 2· 3.2 CH3OH …
(1),[Ni4 (H2chdp) 2 (H2O) 4](PF6) 2 (2) and [Ni4 (H2chdp) 2 (H2O) 4](ClO4) 2· 3.2 CH3OH …
Novel organophosphorus scaffolds of urease inhibitors obtained by substitution of Morita-Baylis-Hillman adducts with phosphorus nucleophiles
V Ntatsopoulos, S Vassiliou, K Macegoniuk… - European Journal of …, 2017 - Elsevier
Abstract The reactivity of Morita-Baylis-Hillman allyl acetates was employed to introduce
phosphorus-containing functionalities to the side chain of the cinnamic acid conjugated …
phosphorus-containing functionalities to the side chain of the cinnamic acid conjugated …
Inhibition of jack bean urease by tetrachloro-o-benzoquinone and tetrachloro-p-benzoquinone
M Kot, W Zaborska - Journal of Enzyme Inhibition and Medicinal …, 2006 - Taylor & Francis
Tetrachloro-o-benzoquinone (TCoBQ) and tetrachloro-p-benzoquinone (TCpBQ) were
studied as inhibitors of jack bean urease in 20 mM phosphate buffer, pH 7.0, 1 mM EDTA …
studied as inhibitors of jack bean urease in 20 mM phosphate buffer, pH 7.0, 1 mM EDTA …