Defining dry eye from a clinical perspective

K Tsubota, SC Pflugfelder, Z Liu, C Baudouin… - International journal of …, 2020 - mdpi.com
Over the past decades, the number of patients with dry eye disease (DED) has increased
dramatically. The incidence of DED is higher in Asia than in Europe and North America …

TFOS DEWS II tear film report

MDP Willcox, P Argüeso, GA Georgiev, JM Holopainen… - The ocular …, 2017 - Elsevier
The members of the Tear Film Subcommittee reviewed the role of the tear film in dry eye
disease (DED). The Subcommittee reviewed biophysical and biochemical aspects of tears …

[HTML][HTML] Inflammatory basis for dry eye disease flares

VL Perez, ME Stern, SC Pflugfelder - Experimental Eye Research, 2020 - Elsevier
Most patients with chronic dry eye disease (DED) have episodic flares, which can be
triggered by a variety of activities and environmental stresses. These flares are typically …

Dry eye disease: an immune-mediated ocular surface disorder

W Stevenson, SK Chauhan, R Dana - Archives of ophthalmology, 2012 - jamanetwork.com
Dry eye disease is a multifactorial disorder of the tears and ocular surface characterized by
symptoms of dryness and irritation. Although the pathogenesis of dry eye disease is not fully …

Dry eye as a mucosal autoimmune disease

ME Stern, CS Schaumburg… - International reviews of …, 2013 - Taylor & Francis
Dry eye is a common ocular surface inflammatory disease that significantly affects quality of
life. Dysfunction of the lacrimal function unit (LFU) alters tear composition and breaks ocular …

Ocular surface immunity: homeostatic mechanisms and their disruption in dry eye disease

S Barabino, Y Chen, S Chauhan, R Dana - Progress in retinal and eye …, 2012 - Elsevier
The tear film, lacrimal glands, corneal and conjunctival epithelia and Meibomian glands
work together as a lacrimal functional unit (LFU) to preserve the integrity and function of the …

Immune privilege and eye‐derived T‐regulatory cells

H Keino, S Horie, S Sugita - Journal of immunology research, 2018 - Wiley Online Library
Certain cellular components of the eye, such as neural retina, are unable to regenerate and
replicate after destructive inflammation. Ocular immune privilege provides the eye with …

Clinical impact of inflammation in dry eye disease: proceedings of the ODISSEY group meeting

C Baudouin, M Irkeç, EM Messmer… - Acta …, 2018 - Wiley Online Library
Dry eye disease (DED) is a common, multifactorial ocular condition with major impact on
vision and quality of life. It is now well recognized that the pathophysiology of chronic DED …

Meibum expressibility improvement as a therapeutic target of intense pulsed light treatment in meibomian gland dysfunction and its association with tear inflammatory …

M Choi, SJ Han, YW Ji, YJ Choi, I Jun, MH Alotaibi… - Scientific reports, 2019 - nature.com
Many recent studies have demonstrated the efficacy of intense pulsed light (IPL) for the
treatment of meibomian gland dysfunction (MGD); however, its effective treatment targets …

[HTML][HTML] Autoimmunity at the ocular surface: pathogenesis and regulation

ME Stern, CS Schaumburg, R Dana, M Calonge… - Mucosal …, 2010 - Elsevier
A healthy ocular surface environment is essential to preserve visual function, and as such
the eye has evolved a complex network of mechanisms to maintain homeostasis …