Acquired chemoresistance during chemotherapy, often accompanied by cross-and multi-
resistance, limits therapeutic outcomes and leads to recurrence. In order to create in vitro …

Simple Summary Prostate cancer (PC) is one of the main types of cancer that affects the
male population worldwide. In recent decades, there has been a significant evolution in the …

Background The origin recognition complex (ORC), a six-subunit DNA-binding complex,
participates in DNA replication in cancer cells. Specifically in prostate cancers, ORC …

Dogs are one of few species that naturally develop prostate cancer (PCa), which clinically
resembles aggressive, advanced PCa in humans. Moreover, PCa-tumor samples from dogs …

Canine prostate cancer is classified into adenocarcinoma, transitional cell carcinoma with
prostatic involvement, and mixed forms. Early metastatic spread leads to poor prognosis and …

In dogs, the most frequent diseases of the prostate gland are benign prostate gland
hyperplasia (BPH), acute and chronic prostatitis, squamous metaplasia, and prostate …

With the growing interest in companion animals and the rapidly expanding animal
healthcare and pharmaceuticals market worldwide. With the advancements in RNA …

Digital twins are made of a real-world component where data is measured and a virtual
component where those measurements are used to parameterize computational models …

The evaluation of toxicity in preclinical species is important for identifying potential safety
liabilities of experimental medicines. Toxicology studies provide translational insight into …

Prostate cancer (PoC) is currently one of the most frequent cancers in males. Though a lot of
work has been done on it, the biomarkers in the progression of prostate cancer have not …