Background & Aims Phosphatidylcholines (PCs) are structural and functional constituents of
cell membranes. The activity of acyltransferase (lysophosphatidylcholine acyltransferase …

Triglycerides are insoluble in water and yet are transported at milligram per millilitre
concentrations in the bloodstream. This is made possible by the ability of the liver and …

Vitamin E supplementation constitutes a promising strategy in the prevention of
neurodegenerative diseases. Here, we show that a phospholipid transfer protein (PLTP) is …

The liver x receptors LXRα (NR1H3) and LXRβ (NR1H2) are members of the nuclear
hormone receptor superfamily of ligand dependent transcription factors that regulate …

Objective—Plasma phospholipid transfer protein (PLTP) mediates both net transfer and
exchange of phospholipids between different lipoproteins. Animal studies have shown that it …

The presence of elevated circulating triacylglycerol (TG)‐rich very low density lipoprotein
(VLDL) and apolipoprotein B‐100 (apoB‐100) levels represents an independent risk factor …

Liver X receptors (LXRs) activate triglyceride synthesis in liver directly and indirectly by
inducing sterol regulatory element-binding protein-1c (SREBP-1c). When administered to …

Abstract Phospholipid Transfer Protein (PLTP) transfers amphiphilic lipids between
circulating lipoproteins and between lipoproteins, cells and tissues. Indeed, PLTP is a major …

KK/Snk mice (previously KK/San) possessing a recessive mutation (hypl) of the angiopoietin-
like 3 (Angptl3) gene homozygously exhibit a marked reduction of VLDL due to the …

Objective: Niacin therapy fails to reduce cardiovascular events in statin-treated subjects
even though it increases plasma HDL-C (HDL [high-density lipoprotein] cholesterol) and …