New Delhi metallo-β-lactamase (NDM) is a metallo-β-lactamase able to hydrolyze almost all
β-lactams. Twenty-four NDM variants have been identified in> 60 species of 11 bacterial …

Polymyxins are well-established antibiotics that have recently regained significant interest
as a consequence of the increasing incidence of infections due to multidrug-resistant Gram …

The introduction of antibiotics into clinical practice revolutionized the treatment and
management of infectious diseases. Before the introduction of antibiotics, these diseases …

The polymyxins, colistin (also known as polymyxin E) and polymyxin B, have a unique and
interesting history. Originally introduced in the 1950s for the treatment of infections due to …

Polymyxins, including polymyxin B and polymyxin E (colistin), are now increasingly being
used worldwide to treat patients with multidrug-resistant (MDR) Gram-negative bacterial …

Polymyxins are last-resort antibiotics re-emerged to treat infections caused by multidrug
resistant (MDR) and extensively drug-resistant (XDR) Gram-negative bacterial infections …

Background: Bacterial resistance to available antibiotics has resulted in enhanced efforts at
antibiotic stewardship but also has led to investigation into alternative methods for managing …

ABSTRACT Introduction: Non-fermenting Gram-negative bacilli are at the center of the
antimicrobial resistance epidemic. Acinetobacter baumannii and Pseudomonas aeruginosa …

Objectives Optimal dosage regimens of colistin for the treatment of urinary tract infections
(UTI) are unknown. Colistimethate sodium (CMS), the inactive prodrug of colistin, is mainly …

Polymyxins have remained the drug of choice for treatment due to carbapenem-resistant
Gram-negative bacilli. Unfortunately, the utility of these agents has been limited by a lack of …