The role of multispecies social interactions in shaping Pseudomonas aeruginosa pathogenicity in the cystic fibrosis lung

S O'Brien, JL Fothergill - FEMS microbiology letters, 2017 - academic.oup.com
Pseudomonas aeruginosa is a major pathogen in the lungs of cystic fibrosis (CF) patients.
However, it is now recognised that a diverse microbial community exists in the airways …

Pf bacteriophage and their impact on Pseudomonas virulence, mammalian immunity, and chronic infections

PR Secor, EB Burgener, M Kinnersley… - Frontiers in …, 2020 - frontiersin.org
Pf bacteriophage are temperate phages that infect the bacterium Pseudomonas aeruginosa,
a major cause of chronic lung infections in cystic fibrosis (CF) and other settings. Pf and …

Bacteriophages in infectious diseases and beyond—A narrative review

P Ioannou, S Baliou, G Samonis - Antibiotics, 2023 - mdpi.com
The discovery of antibiotics has revolutionized medicine and has changed medical practice,
enabling successful fighting of infection. However, quickly after the start of the antibiotic era …

Repair Process Impairment by Pseudomonas aeruginosa in Epithelial Tissues: Major Features and Potential Therapeutic Avenues

M Ruffin, E Brochiero - Frontiers in cellular and infection microbiology, 2019 - frontiersin.org
Epithelial tissues protecting organs from the environment are the first-line of defense against
pathogens. Therefore, efficient repair mechanisms after injury are crucial to maintain …

The microbiome: an integral player in immune homeostasis and inflammation in the respiratory tract

O Perdijk, R Azzoni, BJ Marsland - Physiological Reviews, 2024 - journals.physiology.org
The last decade of microbiome research has highlighted its fundamental role in systemic
immune and metabolic homeostasis. The microbiome plays a prominent role during …

Phigaro: high-throughput prophage sequence annotation

EV Starikova, PO Tikhonova, NA Prianichnikov… - …, 2020 - academic.oup.com
Phigaro is a standalone command-line application that is able to detect prophage regions
taking raw genome and metagenome assemblies as an input. It also produces dynamic …

Cross-resistance is modular in bacteria–phage interactions

RCT Wright, VP Friman, MCM Smith… - PLoS biology, 2018 - journals.plos.org
Phages shape the structure of natural bacterial communities and can be effective
therapeutic agents. Bacterial resistance to phage infection, however, limits the usefulness of …

Exploiting lung adaptation and phage steering to clear pan-resistant Pseudomonas aeruginosa infections in vivo

EA Ashworth, RCT Wright, RK Shears… - Nature …, 2024 - nature.com
Pseudomonas aeruginosa is a major nosocomial pathogen that causes severe disease
including sepsis. Carbapenem-resistant P. aeruginosa is recognised by the World Health …

Comparative analysis of different preservation techniques for the storage of Staphylococcus phages aimed for the industrial development of phage-based …

E Gonzalez-Menendez, L Fernandez, D Gutierrez… - PloS one, 2018 - journals.plos.org
Bacteriophages have been proven as effective antimicrobial agents in the treatment of
infectious diseases and in other biocontrol applications including food preservation and …

[HTML][HTML] Phage therapy against Achromobacter xylosoxidans lung infection in a patient with cystic fibrosis: a case report

N Hoyle, P Zhvaniya, N Balarjishvili, D Bolkvadze… - Research in …, 2018 - Elsevier
Respiratory infections can lead to serious complications in CF patients, especially when
infected with antibiotic resistant bacteria. Alternative treatments for these infections are being …