The target of rapamycin (TOR), discovered 30 years ago, is a highly conserved
serine/threonine protein kinase that plays a central role in regulating cell growth and …

Transcription factor EB (TFEB), a member of the MiT/TFE family of basic helix-loop-helix
leucine zipper transcription factors, is an established central regulator of the …

Old age is associated with a greater burden of disease, including neurodegenerative
disorders such as Alzheimer's disease and Parkinson's disease, as well as other chronic …

Glioblastoma multiforme is one of the calamitous primary glial brain tumors with extensive
heterogeneity at cellular and molecular levels. While maximal surgical resection trailed by …

The detrimental impact of obesity on human health is increasingly evident with the rise in
obesity-related diseases. Skeletal muscle, the crucial organ responsible for energy balance …

Valosin containing protein (VCP) has emerged as a central protein in the regulation of the
protein quality control (PQC) system. VCP mutations are causative of multisystem …

The mechanistic target of rapamycin (mTOR) is evolutionarily conserved from yeast to
humans and is one of the most fundamental pathways of living organisms. Since its …

Background and aim Cigarette smoking is the most common cause of chronic obstructive
pulmonary disease (COPD) but more mechanistic studies are needed. Cigarette smoke …

Acute pancreatitis (AP) is a highly fatal acute inflammation and is often accompanied by
multiple organ dysfunction syndrome (MODS). The liver, one of the most vulnerable …

Non-clear cell renal cell carcinomas are a miscellaneous group of tumors that include
different histological subtypes, each one characterized by peculiarity in terms of genetic …