Noise-induced hearing loss (NIHL) is the second most common cause of sensorineural
hearing loss, after age-related hearing loss, and affects approximately 5% of the world's …

Usher syndrome (USH), clinically and genetically heterogeneous, is the leading genetic
cause of combined hearing and vision loss. USH is classified into three types, based on the …

Primary cilia are solitary, generally non-motile, hair-like protrusions that extend from the
surface of cells between cell divisions. Their antenna-like structure leads naturally to the …

Uniquely among human senses, hearing is not simply a passive response to stimulation.
Our auditory system is instead enhanced by an active process in cochlear hair cells that …

Types of Cell Culture Media Animal cells can be cultured either using a completely natural
medium or an artificial/synthetic medium along with some natural products. Natural Media …

Much is known about the mechanotransducer (MT) channels mediating transduction in hair
cells of the vertrbrate inner ear. With the use of isolated preparations, it is experimentally …

Usher syndrome type 1 F (USH1F), caused by mutations in the protocadherin-15 gene
(PCDH15), is characterized by congenital deafness, lack of balance, and progressive …

Sensory hair cells of the inner ear are exposed to continuous mechanical stress, causing
damage over time. The maintenance of hair cells is further challenged by damage from a …

Mechanosensitive ion channels at stereocilia tips mediate mechanoelectrical transduction
(MET) in inner ear sensory hair cells. Transmembrane channel-like 1 and 2 (TMC1 and …

Most sounds of interest consist of complex, time-dependent admixtures of tones of diverse
frequencies and variable amplitudes. To detect and process these signals, the ear employs …