[HTML][HTML] Galectin-3 induces a pro-degradative/inflammatory gene signature in human chondrocytes, teaming up with galectin-1 in osteoarthritis pathogenesis

D Weinmann, K Schlangen, S André, S Schmidt… - Scientific Reports, 2016 - nature.com
Inflammatory chemo-and cytokines and matrix-degrading proteases underlie the
progression of osteoarthritis (OA). Aiming to define upstream regulators for these disease …

Galectin-3 is a key hepatoprotective molecule against the deleterious effect of cisplatin

DD Santos, GRS Sasso, NM Belote, RA da Silva, I Lice… - Life Sciences, 2023 - Elsevier
Aims Evaluate the role of galectin-3 in the liver using an acute model of cisplatin-induced
toxicity. Material and methods Modified citrus pectin (MCP) treatment was used to inhibit …

Proteomic analysis of isolated membrane fractions from superinvasive cancer cells

P Dowling, P Meleady, A Dowd, M Henry… - … et Biophysica Acta (BBA …, 2007 - Elsevier
The superinvasive phenotype exhibited by paclitaxel-selected variants of an in vitro invasive
clonal population of the human cancer cell line, MDA-MB-435S were examined using DIGE …

Why anti-Bcl-2 clinical trials fail: a solution

Y Harazono, K Nakajima, A Raz - Cancer and Metastasis Reviews, 2014 - Springer
The alteration in expression of B cell lymphoma-2 (Bcl-2) family of protein members in
cancer is involved mainly in the regulation of apoptosis. Bcl-2 family proteins are currently …

Transcriptomics-based characterization of the toxicity of ZnO nanoparticles against chronic myeloid leukemia cells

SA Alsagaby, R Vijayakumar… - International Journal …, 2020 - Taylor & Francis
Introduction Zinc oxide nanoparticles (ZnO NPs) have recently attracted attention as
potential anti-cancer agents. To the best of our knowledge, the toxicity of ZnO NPs against …

The acid and neutral fractions of pectins isolated from ripe and overripe papayas differentially affect galectin-3 inhibition and colon cancer cell growth

L de Freitas Pedrosa, RG Lopes, JP Fabi - International Journal of …, 2020 - Elsevier
The water-soluble fractions of pectin extracted from the pulp of ripe papayas have already
been found to exert positive effects on cancer cell cultures. However, the mechanisms that …

[HTML][HTML] Endogenous galectin-9 suppresses apoptosis in human rheumatoid arthritis synovial fibroblasts

MJ Pearson, MA Bik, C Ospelt, AJ Naylor… - Scientific reports, 2018 - nature.com
Abstract Galectin-9 (Gal9) has been postulated to have anti-inflammatory properties based
on the ability of exogenous Gal9 to induce apoptosis in synovial fibroblasts in animal models …

[HTML][HTML] Epigenetic regulation of galectin-3 expression by β1 integrins promotes cell adhesion and migration

C Margadant, I van den Bout, AL van Boxtel… - Journal of Biological …, 2012 - ASBMB
Introduction of the integrin β1-but not the β3-subunit in GE11 cells induces an epithelial-to-
mesenchymal-transition (EMT)-like phenomenon that is characterized by the loss of cell-cell …

Galectin-3 as a biomarker in breast neoplasms: Mechanisms and applications in patient care

DGM Niang, FM Gaba, A Diouf… - Journal of leukocyte …, 2022 - academic.oup.com
Galectin-3 is a member of the lectin family encoded by the LGALS3 gene on chromosome
14. It is secreted by a wide range of immune cells and mammary tumor cells. Through its …

[HTML][HTML] Early hyperbaric oxygen treatment attenuates burn-induced neuroinflammation by inhibiting the galectin-3-dependent toll-like receptor-4 pathway in a rat …

ZS Wu, JJ Lo, SH Wu, CZ Wang, RF Chen… - International journal of …, 2018 - mdpi.com
Hyperbaric oxygen (HBO) treatment has been proven to decrease neuroinflammation in rats.
This study aimed to determine the potential mechanism underlying the anti-inflammatory …