The discovery of RNA-catalyzed phosphodiester bond cleavage by Cech and Altman in
1982− 1983 shattered the paradigm of protein-dependent biological catalysis and opened …

Abstract G-quadruplex (G4) with stacked G-tetrads structure is able to bind hemin (iron (III)-
protoporphyrin IX) to form a unique type of DNAzyme/RNAzyme with peroxidase-mimicking …

Various self-cleaving ribozymes appearing in nature catalyze the sequence-specific
intramolecular cleavage of RNA and can be engineered to catalyze cleavage of appropriate …

RNA and DNA carry out diverse functions in biology including catalysis, splicing, gene
regulation, and storage of genetic information. Interest has grown in understanding how …

The hammerhead ribozyme is a self-cleaving RNA broadly dispersed across all kingdoms of
life. Although it was the first of the small, nucleolytic ribozymes discovered, the mechanism …

Self-splicing ribozymes are small ribonucleic acid (RNA) enzymes that catalyze their own
cleavage through a transphosphoesterification reaction. While this process is involved in …

The hepatitis delta virus (HDV) ribozyme catalyzes a self-cleavage reaction using a
combination of nucleobase and metal ion catalysis. Both divalent and monovalent ions can …

RNA tertiary structure motifs are stabilized by a wide variety of hydrogen‐bonding
interactions. Protonated A and C nucleotides are normally not considered to be suitable …

Nucleolytic ribozymes catalyze site‐specific cleavage of their phosphodiester backbones. A
minimal version of the twister ribozyme is reported that lacks the phylogenetically conserved …

The catalytic strategies of small self-cleaving ribozymes often involve interactions between
nucleobases and the ribonucleic acid (RNA) backbone. Here we show that multiply …