Around 3% of the genome consists of simple DNA repeats that are prone to forming
alternative (non-B) DNA structures, such as hairpins, cruciforms, triplexes (H-DNA), four …

Alternative DNA structures that differ from the canonical B-form of DNA can arise from
repetitive sequences and play beneficial roles in many cellular processes such as gene …

Apes possess two sex chromosomes—the male-specific Y chromosome and the X
chromosome, which is present in both males and females. The Y chromosome is crucial for …

Epstein–Barr virus (EBV) is an oncogenic herpesvirus associated with several cancers of
lymphocytic and epithelial origin,–. EBV encodes EBNA1, which binds to a cluster of 20 …

CANVAS is a recently characterized repeat expansion disease, most commonly caused by
homozygous expansions of an intronic (A2G3) n repeat in the RFC1 gene. There are a …

The compaction and organization of genomic DNA is a central mechanism in eukaryotic
cells, but engineered architectural control over double‐stranded DNA (dsDNA) is notably …

DNA damage is a threat to genome integrity and can be a cause of many human diseases,
owing to either changes in the chemical structure of DNA or conversion of the damage into a …

Conspectus Biomimetics is defined as a “practice of making technological design that copies
natural processes”, with the idea that “nature has already solved the challenges we are …

Sequences capable of forming quadruplex or G4 DNA are prevalent in the promoter regions.
The transformation from canonical to non-canonical secondary structure apparently …

G-quadruplex (G4) selective stabilizing ligands can regulate c-MYC gene expression, but
the kinetic basis remains unclear. Determining the effects of ligands on c-MYC promoter …