Acromegaly is a chronic systemic disease with many complications and is associated with
increased mortality when not adequately treated. Substantial advances in acromegaly …

Background Acromegaly is a rare and underdiagnosed disorder caused, in more than 95%
of cases, by a growth hormone (GH)-secreting pituitary adenoma. The GH hypersecretion …

Context: Acromegaly is usually due to the excessive secretion of GH by a pituitary adenoma.
It is frequently accompanied by comorbidities that compromise quality of life and results in …

Introduction Acromegaly is a rare, insidious disease resulting from the overproduction of
growth hormone (GH) and insulin-like growth factor 1 (IGF-1), and is associated with a range …

Context Acromegaly has been associated with increased risk of cancer morbidity and
mortality, but research findings remain conflicting and population-based data are scarce. We …

The insulin-like growth factor (IGF) pathway comprises two activating ligands (IGF-I and IGF-
II), two cell-surface receptors (IGF-IR and IGF-IIR), six IGF binding proteins (IGFBP) and nine …

Context: GH and IGF-1 have been shown to affect tumor growth in vitro and in some animal
models. This report summarizes the available evidence on whether GH therapy in childhood …

Introduction Acromegaly is a quite rare chronic disease caused by the increased secretion of
growth hormone (GH) and subsequently insulin-like growth factor 1. Although …

Based on experimental and animal models, epidemiological data from non-acromegaly
populations, and longitudinal and cross-sectional cohorts of patients with acromegaly, a …

Androgen-deprivation therapy (ADT) is the standard treatment for metastatic prostate cancer.
One factor that has been implicated in the metastatic process is the cell adhesion molecule …