[HTML][HTML] Physiologically Based Pharmacokinetics Modeling in the Neonatal Population—Current Advances, Challenges, and Opportunities
Physiologically based pharmacokinetic (PBPK) modeling is an approach to predicting drug
pharmacokinetics, using knowledge of the human physiology involved and drug …
pharmacokinetics, using knowledge of the human physiology involved and drug …
[HTML][HTML] Investigating Tacrolimus Disposition in Paediatric Patients with a Physiologically Based Pharmacokinetic Model Incorporating CYP3A4 Ontogeny, Mechanistic …
M Van der Veken, J Brouwers, AC Ozbey, K Umehara… - Pharmaceutics, 2023 - mdpi.com
Tacrolimus is a crucial immunosuppressant for organ transplant patients, requiring
therapeutic drug monitoring due to its variable exposure after oral intake. Physiologically …
therapeutic drug monitoring due to its variable exposure after oral intake. Physiologically …
Prediction of Pediatric Pharmacokinetics for CYP3A4 Metabolized Drugs: Comparison of the Performance of Two Hepatic Ontogeny Within a Physiologically Based …
M Codaccioni, RL Southall, J Dinh… - The Journal of Clinical …, 2024 - Wiley Online Library
The rapid growth in the use of pediatric physiologically based pharmacokinetic (PBPK)
models, particularly for regulatory applications, has focused emphasis on model verification …
models, particularly for regulatory applications, has focused emphasis on model verification …
Development and Verification of a Japanese Pediatric Physiologically Based Pharmacokinetic Model with Emphasis on Drugs Eliminated by Cytochrome P450 or …
TN Johnson, K Abduljalil, X Pan… - The Journal of Clinical …, 2023 - Wiley Online Library
Physiologically based pharmacokinetic (PBPK) models are useful in bridging drug exposure
in different ethnic groups, and there is increasing regulatory application of this approach in …
in different ethnic groups, and there is increasing regulatory application of this approach in …