In the two and a half years following our initial paper on the humoral theory of
transplantation, many publications have emerged in support of the hypothesis, with no …

Cardiac transplantation is the most effective treatment for advanced heart failure. Despite
improvements in immunosuppression therapy that prevent acute rejection, cardiac allografts …

Not unlike Tolstoy's remark about happy versus unhappy families, current wisdom in
vascular biology holds that healthy blood vessels are mostly similar, whereas vessels in …

Rationale: ASK1-interacting protein-1 (AIP1), a Ras GTPase-activating protein family
member, is highly expressed in endothelial cells and vascular smooth musccells (VSMCs) …

Background—The development of autoantibody after heart transplantation is increasingly
associated with poor graft outcome, but what triggers its development and whether it has a …

Objectives: The aim of this study was to determine the role of suppressor of cytokine
signaling 1 (SOCS1) in graft arteriosclerosis (GA). Background: GA, the major cause of late …

Background. Transplant vasculopathy (TV) is the most significant obstacle to long-term
success of organ transplantation. Increasing attention has been paid to the role of adventitia …

Objective: AIP1 expression is downregulated in human atherosclerotic plaques and global
deletion of AIP1 in mice exacerbates atherosclerosis in ApoE-KO mouse models. However …

Graft arteriosclerois (GA), also called allograft vasculopathy, is a pathologic lesion that
develops over months to years in transplanted organs characterized by diffuse …

Background Cardiac allograft vasculopathy (AV) is a pathological process of vascular
remodeling leading to late graft loss following cardiac transplantation. While there is …