Cytochrome P450 (CYP450) enzymes are membrane-bound blood proteins that are vital to
drug detoxification, cell metabolism, and homeostasis. CYP450s belonging to CYP families …

Cells utilize a diverse repertoire of cell surface and intracellular receptors to detect
exogenous or endogenous danger signals and even the changes of their microenvironment …

CYP2J2 as an endoplasmic reticulum (ER)-expressed vital cytochrome P450 isoform
participates in the metabolism of endogenous polyunsaturated fatty acids. Its abnormal …

Our study aims to verify the potential effects and underlying mechanisms of IL-37 in
Coxsackievirus B3 (CVB3)-induced viral myocarditis (VMC). VMC model was established by …

Endotoxemia elicits a multiorgan inflammatory response that results in cardiac dysfunction
and often leads to death. Inflammation-induced metabolism of endogenous N-3 and N-6 …

ABSTRACT Introduction Cytochrome P450s (CYPs) are a superfamily of monooxygenases
with diverse biological roles. CYP2J2 is an isozyme highly expressed in the heart where it …

This study was designed to investigate the roles of spermidine on lipopolysaccharide (LPS)-
induced macrophage activation and underlying mechanisms. Spermidine was found to …

Oxylipins have garnered increasing attention because they were consistently shown to play
pathological and/or pharmacological roles in the development of multiple cancers. Oxylipins …

Abstract Background Dexmedetomidine (Dex) is a safe and effective anesthetic adjunct
which also has neuroprotective roles. This study aimed to validate the role of Dex in hypoxic …

Among nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs), NOD-like
receptor X1 (NLRX1) is the only known NLR family member that is targeted to the …