Therapeutic potential of ectopic olfactory and taste receptors

SJ Lee, I Depoortere, H Hatt - Nature Reviews Drug Discovery, 2019 - nature.com
Olfactory and taste receptors are expressed primarily in the nasal olfactory epithelium and
gustatory taste bud cells, where they transmit real-time sensory signals to the brain …

[HTML][HTML] An evolutionary perspective on food and human taste

PAS Breslin - Current Biology, 2013 - cell.com
The sense of taste is stimulated when nutrients or other chemical compounds activate
specialized receptor cells within the oral cavity. Taste helps us decide what to eat and …

Structure-function of CD36 and importance of fatty acid signal transduction in fat metabolism

MY Pepino, O Kuda, D Samovski… - Annual review of …, 2014 - annualreviews.org
CD36 (cluster of differentiation 36) is a scavenger receptor that functions in high-affinity
tissue uptake of long-chain fatty acids (FAs) and contributes under excessive fat supply to …

Oleogustus: the unique taste of fat

CA Running, BA Craig, RD Mattes - Chemical senses, 2015 - academic.oup.com
Considerable mechanistic data indicate there may be a sixth basic taste: fat. However,
evidence demonstrating that the sensation of nonesterified fatty acids (NEFA, the proposed …

Taste of fat: a sixth taste modality?

P Besnard, P Passilly-Degrace… - Physiological …, 2016 - journals.physiology.org
An attraction for palatable foods rich in lipids is shared by rodents and humans. Over the last
decade, the mechanisms responsible for this specific eating behavior have been actively …

[HTML][HTML] The fatty acid translocase gene CD36 and lingual lipase influence oral sensitivity to fat in obese subjects

MY Pepino, L Love-Gregory, S Klein… - Journal of lipid …, 2012 - ASBMB
The precise orosensory inputs engaged for dietary lipids detection in humans are unknown.
We evaluated whether a common single nucleotide polymorphism (rs1761667) in the CD36 …

Sugar reduction without compromising sensory perception. An impossible dream?

SC Hutchings, JYQ Low, RSJ Keast - Critical reviews in food …, 2019 - Taylor & Francis
Sugar reduction is a major technical challenge for the food industry to address in response
to public health concerns regarding the amount of added sugars in foods. This paper …

[HTML][HTML] Reduced dietary intake of simple sugars alters perceived sweet taste intensity but not perceived pleasantness

PM Wise, L Nattress, LJ Flammer… - The American journal of …, 2016 - Elsevier
Background: Individuals who adhere to reduced-sodium diets come to prefer less salt over
time, but it is unclear whether sweet taste perception is modulated by reduced sugar intake …

Endocannabinoids in the Gut

NV DiPatrizio - Cannabis and cannabinoid research, 2016 - liebertpub.com
Cannabis has been used medicinally for centuries to treat a variety of disorders, including
those associated with the gastrointestinal tract. The discovery of our bodies' own “cannabis …

Role of gut nutrient sensing in stimulating appetite and conditioning food preferences

A Sclafani, K Ackroff - American Journal of Physiology …, 2012 - journals.physiology.org
The discovery of taste and nutrient receptors (chemosensors) in the gut has led to intensive
research on their functions. Whereas oral sugar, fat, and umami taste receptors stimulate …