Membrane proteins play a most important part in metabolism, signaling, cell motility,
transport, development, and many other biochemical and biophysical processes which …

Membrane proteins have long presented a challenge to biochemical and functional studies.
In the absence of a bilayer environment, individual proteins and critical macromolecular …

Suitable membrane mimetics are crucial to the performance of structural and functional
studies of membrane proteins. Phospholipid nanodiscs (formed when a membrane scaffold …

Membrane proteins (MPs) play essential roles in numerous cellular processes. Because
around 70% of the currently marketed drugs target MPs, a detailed understanding of their …

Membrane-protein NMR occupies a unique niche for determining structures, assessing
dynamics, examining folding, and studying the binding of lipids, ligands and drugs to …

Historically, the main barrier to membrane protein investigations has been the tendency of
membrane proteins to aggregate (due to their hydrophobic nature), in aqueous solution as …

Membrane proteins are important players in signal transduction and the exchange of
metabolites within or between cells. Thus, this protein class is the target of around 60% of …

Compared to soluble protein counterparts, the understanding of membrane protein stability,
solvent interactions, and function are not as well understood. Recent advancements in …

Ras genes potently drive human cancers, with mutated proto-oncogene GTPase KRAS4B (K-
Ras4B) being the most abundant isoform. Targeted inhibition of oncogenic gene products is …

Simple Summary Cells, life's smallest units, are defined within the enclosure of thin,
continuous membranes, which confine the molecular machinery required for the life and …