Abstract Surfactant Protein B (SP-B) deficiency has been recently identified as an
uncommon, autosomal recessive lung disorder in term infants. This inability to produce SP-B …

We examined the ability of the human surfactant protein B (SP-B) promoter to confer cell
specificity of transgene expression in an adenoviral vector. Using similar replication …

Background. To study computed tomographic (CT) findings in children with pulmonary
alveolar proteinosis (PAP) more extensively. Objective. To describe the CT features at the …

Although genetic factors are assumed to have a role in the etiology of respiratory distress
syndrome (RDS), specific genes underlying this susceptibility are incompletely known. The …

Exogenous surfactant is one of only a handful of neonatal therapies that has a strong
evidence base, the product of countless basic and clinical studies over roughly 30 years …

Aaron Hamvas, MD ulmonary surfactant is a complex mixture of p phospholipid and protein
that is synthesized--by alveolar type II pneumocytes and is necessary to maintain alveolar …

This study investigates the activity and inhibition resistance in excised rat lungs of a novel
synthetic surfactant containing the phospholipase-resistant diether phosphonolipid DEPN-8 …

Hereditary surfactant protein B (SP-B) deficiency is an uncommon autosomal recessive lung
disorder that causes hypoxemic respiratory failure in mature, morphologically normal infants …

Neonatal respiratory distress syndrome is the most frequent respiratory cause of death and
morbidity in the first year of life in the United States [1–3]. Pulmonary morbidity in survivors of …

The content-dependent activity of surfactant protein (SP)-B was studied in mixtures with
dipalmitoyl phosphatidylcholine (DPPC), synthetic lipids (SL), and purified phospholipids …