We report on the DNA‐based prenatal diagnosis of congenital pulmonary alveolar
proteinosis in a family in which alveolar proteinosis was associated with surfactant protein B …

IN THE REPORT FROM MELTON ET AL., one of the current articles in focus (Ref. 21, see p.
L543 in this issue), they use genetically engineered mice to demonstrate that at least 25% of …

Background: Full-term infants with severe and prolonged respiratory distress represent a
diagnostic challenge. Plain radiographic findings may be nonspecific or similar to classic …

Congenital alveolar proteinosis is a recently described cause of lung dysfunction and
respiratory distress in term neonates. In several cases a deficiency or insufficiency of …

Pulmonary surfactant is a complex mixture of phospholipid and protein that is synthesized by
alveolar type II pneumocytes and is critical for maintaining alveolar expansion at end …

Fatal respiratory distress in term infants is rare and possible causes include persistent fetal
circulation, meconium aspiration syndrome, pneumonia or congen-ital heart and lung …

Successful transition to air breathing at birth depends on perinatal maturation of the gas
exchange surface, resorption of fluid from the air spaces, and synthesis and secretion of …

This chapter examines exogenous surfactant therapy and its utility in miti-gating clinical
acute lung injury (ALI) and the acute respiratory distress syndrome (ARDS). Extensive …

Figure 19.1 Incidence of RDS at different gestations.(Adapted from Greenough, A., Morley,
CJ, Roberton, NRC (1992) Acute respiratory disease in the newborn. In Roberton, NRC …

Alveolarproteinosen sind seltene Lungenerkrankungen, die durch eine intraalveoläre
Akkumulation des Surfactantprotein (SP-) A charakterisiert sind. Folgende Subtypen können …