One in three adults with major depressive disorder (MDD) do not experience clinically
significant improvement after multiple sequential courses of antidepressants and have …

Importance Psilocybin shows promise as a treatment for major depressive disorder (MDD).
Objective To evaluate the magnitude, timing, and durability of antidepressant effects and …

Treatment‐resistant depression (TRD) is common and associated with multiple serious
public health implications. A consensus definition of TRD with demonstrated predictive utility …

Major depressive disorder (MDD) is an often chronic and/or recurrent disorder that is
associated with dysfunctions in multiple aspects of life including work and non-workrelated …

Background: Cognitive behavioural therapy (CBT) is an effective treatment for depression
but a significant minority of clients do not complete therapy, do not respond to it, or …

Mental health treatment advances-including neuropsychiatric medications and devices,
psychotherapies, and cognitive treatments-lag behind other fields of clinical medicine such …

Introduction Understanding how age affects antidepressant response in patients with major
depressive disorder has been complicated by small and heterogeneous studies. Yet …

The relationship between gut microbiota (GM) and mental health is one of the focuses of
psychobiology research. In recent years, the microbial-gut-brain axis (MGBA) concept has …

The reliable change index (RCI) is a widely used statistical tool to account for measurement
error when evaluating difference scores. However, there is considerable debate regarding …

Patients with chronic pain often suffer with depressive symptoms, and these two conditions
can be aggravated by each other over time, leading to an increase in symptom intensity and …