Endurance exercise is a widely accessible, low-cost intervention with a variety of benefits to
multiple organ systems. Exercise improves multiple indices of physical performance and …

Misfolded proteins in the central nervous system can induce oxidative damage, which can
contribute to neurodegenerative diseases in the mitochondria. Neurodegenerative patients …

Amyotrophic lateral sclerosis (ALS) is a rapidly progressive and highly fatal
neurodegenerative disease. Although the pathogenesis of ALS remains unclear, increasing …

Neurological disorders such as stroke, Alzheimer's and Parkinson's diseases are associated
with high morbidity and mortality, and few or no effective options are available for their …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterised by
progressive muscular paralysis reflecting degeneration of motor neurones in the primary …

Exposure to a variety of toxins and/or infectious agents leads to disease, degeneration and
death, often characterised by circumstances in which cells or tissues do not merely die and …

Background In a phase 2 study, dexpramipexole (25–150 mg twice daily) was well tolerated
for up to 9 months and showed a significant benefit at the high dose in a combined …

In the present article, we review the many facets of mitochondrial dysfunction in amyotrophic
lateral sclerosis (ALS), a fatal neurodegenerative disease due to loss of upper motor …

Over the last decade, a piece of the research studying copper role in biological systems was
devoted to unravelling a still elusive, but extremely intriguing, aspect that is the involvement …

Several neurodegenerative diseases share common neuropathology, primarily featuring the
presence in the brain of abnormal protein inclusions containing specific misfolded proteins …