COVID-19 and cellular senescence

CA Schmitt, T Tchkonia, LJ Niedernhofer… - Nature Reviews …, 2023 - nature.com
The clinical severity of coronavirus disease 2019 (COVID-19) is largely determined by host
factors. Recent advances point to cellular senescence, an ageing-related switch in cellular …

Mechanisms and regulation of cellular senescence

L Roger, F Tomas, V Gire - International journal of molecular sciences, 2021 - mdpi.com
Cellular senescence entails a state of an essentially irreversible proliferative arrest in which
cells remain metabolically active and secrete a range of pro-inflammatory and proteolytic …

Association between COVID‐19 and telomere length: a bidirectional Mendelian randomization study

D Huang, S Lin, J He, Q Wang… - Journal of medical …, 2022 - Wiley Online Library
Several traditional observational studies suggested an association between COVID‐19 and
leukocyte telomere length (LTL), a biomarker for biological age. However, whether there …

Immunosenescence and COVID-19

JM Witkowski, T Fulop, E Bryl - Mechanisms of ageing and development, 2022 - Elsevier
Ageing is associated with modified function of both innate and adaptive immunity. It is
believed that changes occurring in ageing immune system are responsible for increased …

[HTML][HTML] Why senescent cells are resistant to apoptosis: an insight for senolytic development

L Hu, H Li, M Zi, W Li, J Liu, Y Yang, D Zhou… - Frontiers in Cell and …, 2022 - frontiersin.org
Cellular senescence is a process that leads to a state of irreversible cell growth arrest
induced by a variety of intrinsic and extrinsic stresses. Senescent cells (SnCs) accumulate …

TNF‐α/IFN‐γ synergy amplifies senescence‐associated inflammation and SARS‐CoV‐2 receptor expression via hyper‐activated JAK/STAT1

R Kandhaya‐Pillai, X Yang, T Tchkonia, GM Martin… - Aging cell, 2022 - Wiley Online Library
Older age and underlying conditions such as diabetes/obesity or immunosuppression are
leading host risk factors for developing severe complications from COVID‐19 infection. The …

[HTML][HTML] Neutrophil extracellular traps and long COVID

A Shafqat, MH Omer, I Albalkhi… - Frontiers in …, 2023 - frontiersin.org
Post-acute COVID-19 sequelae, commonly known as long COVID, encompasses a range of
systemic symptoms experienced by a significant number of COVID-19 survivors. The …

[HTML][HTML] Shared miRNA landscapes of COVID-19 and neurodegeneration confirm neuroinflammation as an important overlapping feature

S Redenšek Trampuž, D Vogrinc, K Goričar… - Frontiers in molecular …, 2023 - frontiersin.org
Introduction: Development and worsening of most common neurodegenerative diseases,
such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis, have been …

Development of nanozymes for promising alleviation of COVID-19-associated arthritis

D Li, B Zhao, P Zhuang, X Mei - Biomaterials Science, 2023 - pubs.rsc.org
The COVID-19 pandemic caused by SARS-CoV-2 has been identified as a culprit in the
development of a variety of disorders, including arthritis. Although the emergence of arthritis …

Effective virus-specific T-cell therapy for high-risk SARS-CoV-2 infections in hematopoietic stem cell transplant recipients: initial case studies and literature review

L Gopcsa, M Réti, H Andrikovics, I Bobek, G Bekő… - GeroScience, 2024 - Springer
The COVID-19 pandemic has exacerbated mortality rates among immunocompromised
patients, accentuating the need for novel, targeted therapies. Transplant recipients, with their …