The amyotrophic lateral sclerosis exposome: recent advances and future directions

SA Goutman, MG Savelieff, DG Jang, J Hur… - Nature Reviews …, 2023 - nature.com
Amyotrophic lateral sclerosis (ALS) is a fatal disease of motor neuron degeneration with
typical survival of only 2–5 years from diagnosis. The causes of ALS are multifactorial …

Nearly 30 years of animal models to study amyotrophic lateral sclerosis: a historical overview and future perspectives

T Bonifacino, RA Zerbo, M Balbi, C Torazza… - International journal of …, 2021 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a fatal, multigenic, multifactorial, and non-cell
autonomous neurodegenerative disease characterized by upper and lower motor neuron …

Advances in zebrafish as a comprehensive model of mental disorders

L Wang, F Liu, Y Fang, J Ma, J Wang, L Qu… - Depression and …, 2023 - Wiley Online Library
As an important part in international disease, mental disorders seriously damage human
health and social stability, which show the complex pathogenesis and increasing incidence …

Swimming against ALS: How to model disease in zebrafish for pathophysiological and behavioral studies

NAS Oliveira, BR Pinho, JMA Oliveira - Neuroscience & Biobehavioral …, 2023 - Elsevier
Abstract Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease that leads to
progressive disability and motor impairment. Existing therapies provide modest …

Fly for ALS: Drosophila modeling on the route to amyotrophic lateral sclerosis modifiers

F Liguori, S Amadio, C Volonté - Cellular and Molecular Life Sciences, 2021 - Springer
Amyotrophic lateral sclerosis (ALS) is a rare, devastating disease, causing movement
impairment, respiratory failure and ultimate death. A plethora of genetic, cellular and …

[HTML][HTML] Edaravone counteracts redox and metabolic disruptions in an emerging zebrafish model of sporadic ALS

NAS Oliveira, BR Pinho, J Pinto, PG de Pinho… - Free Radical Biology …, 2024 - Elsevier
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease in which the death of
motor neurons leads to loss of muscle function. Additionally, cognitive and circadian …

Organ on a Chip: A Novel in vitro Biomimetic Strategy in Amyotrophic Lateral Sclerosis (ALS) Modeling

B Arjmand, S Kokabi Hamidpour, Z Rabbani… - Frontiers in …, 2022 - frontiersin.org
Amyotrophic lateral sclerosis is a pernicious neurodegenerative disorder that is associated
with the progressive degeneration of motor neurons, the disruption of impulse transmission …

Novel P2X7 antagonist ameliorates the early phase of ALS disease and decreases inflammation and autophagy in SOD1-G93A mouse model

S Apolloni, P Fabbrizio, S Amadio, G Napoli… - International journal of …, 2021 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a disease with a resilient neuroinflammatory
component caused by activated microglia and infiltrated immune cells. How to successfully …

SOD-1 Variants in Amyotrophic Lateral Sclerosis: Systematic Re-Evaluation According to ACMG-AMP Guidelines

P Ruffo, B Perrone, FL Conforti - Genes, 2022 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is the most common type of motor neuron disease
whose causes are unclear. The first ALS gene associated with the autosomal dominant form …

Retinoic acid-differentiated neuroblastoma SH-SY5Y Is an accessible in vitro model to study native human acid-sensing ion channels 1a (ASIC1a)

AP Kalinovskii, DI Osmakov, SG Koshelev, KI Lubova… - Biology, 2022 - mdpi.com
Simple Summary Human neuroblastoma SH-SY5Y is used in neurobiology for studying
various neuropathophysiological processes. In this study, we differentiated neuroblastoma …