Adult T-cell leukemia/lymphoma (ATL) is a malignancy of mature CD4+ T cells induced by
human T-cell leukemia virus type I (HTLV-1). HTLV-1 maintains life-long infection in the …

Human Tcell leukemia virus type 1 (HTLV1) was discovered in the 1980s, but it is
estimated to have been infecting humans for more than ten thousand years. 1 With over 90 …

Human T-cell leukemia virus type 1 (HTLV-1) is the causative infectious agent of adult T-cell
leukemia/lymphoma (ATL) and chronic neurological disease. The disparity between …

The genome of retroviruses contains two promoter elements (called long terminal repeat or
LTR) at the 5′ and 3′ end of their genome. Although the expression of retroviral genes …

Human T-cell leukemia virus type 1 (HTLV-1), a retrovirus which mainly infects CD4+ T cells
and causes adult T-cell leukemia/lymphoma (ATL), is primarily transmitted via direct cell-to …

Human T-cell leukemia virus type 1 (HTLV-1) is the etiologic cause of adult T-cell
leukemia/lymphoma (ATL) and encodes a viral oncoprotein (Hbz) that is consistently …

HTLV-1 is an oncogenic human retrovirus and the etiologic agent of the highly aggressive
ATL malignancy. Two viral genes, Tax and Hbz, are individually linked to oncogenic …

Eukaryotic cells employ a broad range of mechanisms to regulate gene expression. Among
others, mRNA alternative splicing is a key process. It consists of introns removal from an …

A typical HTLV-1-infected individual carries> 104 different HTLV-1-infected T cell clones,
each with a single-copy provirus integrated in a unique genomic site. We previously showed …

Cancer immunotherapy has transformed treatment possibilities, but its effectiveness differs
significantly among patients, indicating the presence of alternative pathways for immune …