Regulatory T-cells (Tregs) act at the interface of host and pathogen interactions in human
infectious diseases. Tregs are induced by a wide range of pathogens, but distinct effects of …

Newly discovered anti-cancer immunotherapies, such as immune checkpoint inhibitors and
chimeric antigen receptor T cells, focus on spurring the anti-tumor effector T cell (Teff) …

Rationale: Neuroinflammation is a primary feature of Alzheimer's disease (AD), for which an
increasing number of drugs have been specifically developed. The present study aimed to …

Regulatory T cells (Tregs) suppress immune responses and thus contribute to immune
homeostasis. On the downside, Tregs also limit immune responses against tumors …

Regulatory T (Treg) cells play crucial roles in health and disease through their
immunosuppressive properties against various immune cells. In this review we will focus on …

Mycobacterium tuberculosis (Mtb), the causative agent of human tuberculosis, is able to
efficiently manipulate the host immune system establishing chronic infection, yet the …

The role of Foxp3+ regulatory T (Treg) cells in the course of the early hyper‐inflammatory
and subsequent hypo‐inflammatory phases of sepsis is ambiguous. Whereas Nrp1 …

In human paracoccidioidomycosis (PCM), a primary fungal infection typically diagnosed
when the disease is already established, regulatory T cells (Treg) cells are associated with …

Foxp3 specifies the T reg cell lineage and is indispensable for immune tolerance.
Accordingly, rare Foxp3 mutations cause lethal autoimmunity. The mechanisms precipitating …

Patients with idiopathic pulmonary fibrosis (IPF) can experience life-threatening episodes of
acute worsening of their disease, termed acute exacerbation of IPF, which may be caused …