Skeletal muscle is the largest tissue in the body and loss of its function or its regenerative
properties results in debilitating musculoskeletal disorders. Understanding the mechanisms …

Vitamin A metabolite retinoic acid (RA) plays important roles in cell growth, differentiation,
organogenesis, and reproduction and a key role in mucosal immune responses. RA …

The human kidney contains up to 2 million epithelial nephrons responsible for blood
filtration. Regenerating the kidney requires the induction of the more than 20 distinct cell …

Retinoic acid (RA) signalling has a central role during vertebrate development. RA
synthesized in specific locations regulates transcription by interacting with nuclear RA …

Retinoic acid (RA) is a vitamin A-derived, non-peptidic, small lipophilic molecule that acts as
ligand for nuclear RA receptors (RARs), converting them from transcriptional repressors to …

There are 18 mammalian cytochrome P450 (CYP) families, which encode 57 genes in the
human genome. CYP2, CYP3 and CYP4 families contain far more genes than the other 15 …

Segmentation of the paraxial mesoderm is a major event of vertebrate development that
establishes the metameric patterning of the body axis. This process involves the periodic …

The broad spectrum herbicide glyphosate is widely used in agriculture worldwide. There has
been ongoing controversy regarding the possible adverse effects of glyphosate on the …

The requirement for vitamin A in reproduction was first recognized in the early 1900's, and its
importance in the eyes of developing embryos was realized shortly after. A greater …

Mutations in BRCA1 and BRCA2 confer a high risk of breast and ovarian cancer 1, but
account for only a small fraction of breast cancer susceptibility 1, 2. To find additional genes …