In recent years, the lymphocyte-specific protein tyrosine kinase (Lck) has emerged as one of
the key molecules regulating T-cell functions. Studies using Lck knock-out mice or Lck …

Objective: Triple-negative breast cancer (TNBC) is a high heterogeneity cancer. The
identification of genomic aberrations that drive each of the TNBC subtypes may predict the …

Abstract Lymphocyte cytosolic protein 2 (LCP2) is one of the SLP-76 family of adapters,
which are critical intermediates in signal cascades downstream of several receptors. LCP2 …

Abstract Objective Rates of IgE‐mediated food allergy (FA) have increased over the last few
decades, and mounting evidence implicates disruption of epigenetic profiles in various …

Objective Lymphocyte cytosolic protein 2 (LCP2) is often ectopically expressed in various
human tumors. However, the clinical significance and role of LCP2 in lung adenocarcinoma …

The molecular landscape of chronic lymphocytic leukemia (CLL) has been extensively
characterized, and various potent prognostic biomarkers were discovered. The genetic …

Background: Kidney renal clear cell carcinoma (KIRC) is the most prevalent type of renal cell
carcinoma (RCC), with a high incidence and mortality rate. There is a lack of sensitive …

Inhibiting the functional role of negative regulators in immune cells is an effective approach
for developing immunotherapies. The serine/threonine kinase hematopoietic progenitor …

Introduction: Btk is a tyrosine kinase dysregulated in several B-cell malignancies and
autoimmune diseases, and this has given rise to a search for Btk inhibitors. Nevertheless …

Background Esophageal squamous cell carcinoma (ESCC) is the most common histological
type of esophageal cancer in the world with high incidence rate and poor prognosis …