Somlyo, Andrew P., and Avril V. Somlyo. Ca2+ Sensitivity of Smooth Muscle and Nonmuscle
Myosin II: Modulated by G Proteins, Kinases, and Myosin Phosphatase. Physiol Rev 83 …

Guanine nucleotide-exchange factors (GEFs) are directly responsible for the activation of
Rho-family GTPases in response to diverse extracellular stimuli, and ultimately regulate …

Rho GTPases control many aspects of cell behavior through the regulation of multiple signal
transduction pathways (Van Aelst and D'Souza-Schorey 1997; Hall 1998). Rho, Rac, and …

Rho GTPases represent a family of small GTP-binding proteins involved in cell cytoskeleton
organization, migration, transcription, and proliferation. A common theme of these processes …

Our brain serves as a center for cognitive function and neurons within the brain relay and
store information about our surroundings and experiences. Modulation of this complex …

RAS-related C3 botulinum toxin substrate 1 (Rac. 1) is one of the important members of Rho
GTPases. It is well known that Rac1 is a cytoskeleton regulation protein that regulates cell …

In modern clinical neuro-oncology, histopathological diagnosis affects therapeutic decisions
and prognostic estimation more than any other variable. Among high-grade gliomas …

Rho/Rac proteins constitute a subgroup of the Ras superfamily of GTP hydrolases. Although
originally implicated in the control of cytoskeletal events, it is currently known that these …

Rac1, a member of the Rho family of GTPases, is an intracellular transducer known to
regulate multiple signaling pathways that control cytoskeleton organization, transcription …

Rho GTPases have been implicated in diverse cellular functions and are potential
therapeutic targets. By virtual screening, we have identified a Rho-specific inhibitor, Rhosin …