The role of miRNAs in liver diseases: Potential therapeutic and clinical applications

AS Doghish, MS Elballal, O Elazazy… - … -Research and Practice, 2023 - Elsevier
MicroRNAs (miRNAs) are a class of short, non-coding RNAs that function post-
transcriptionally to regulate gene expression by binding to particular mRNA targets and …

[HTML][HTML] Alcohol-associated liver disease

B Mackowiak, Y Fu, L Maccioni… - The Journal of Clinical …, 2024 - Am Soc Clin Investig
Alcohol-associated liver disease (ALD) is a major cause of chronic liver disease worldwide,
and comprises a spectrum of several different disorders, including simple steatosis …

Flexible photoelectrochemical biosensor for ultrasensitive microRNA detection based on concatenated multiplex signal amplification

Y Zhao, J Xiang, H Cheng, X Liu, F Li - Biosensors and Bioelectronics, 2021 - Elsevier
Precise microRNA (miRNA) analysis is significant importance for early disease diagnosis.
Herein, a novel flexible photoelectrochemical (PEC) biosensor for miRNA determination was …

[HTML][HTML] Crosstalk between oxidative stress and inflammatory liver injury in the pathogenesis of alcoholic liver disease

YM Yang, YE Cho, S Hwang - International journal of molecular sciences, 2022 - mdpi.com
Alcoholic liver disease (ALD) is characterized by the injury, inflammation, and scarring in the
liver owing to excessive alcohol consumption. Currently, ALD is a leading cause for liver …

[HTML][HTML] MicroRNA therapeutics in cancer: current advances and challenges

S Reda El Sayed, J Cristante, L Guyon, J Denis… - Cancers, 2021 - mdpi.com
Simple Summary Cancer is a complex disease associated with deregulation of numerous
genes. In addition, redundant cellular pathways limit efficiency of monotarget drugs in …

miRNAs inspirations in hepatocellular carcinoma: detrimental and favorable aspects of key performers

HA El-Mahdy, AAM Sallam, A Ismail… - … -Research and practice, 2022 - Elsevier
Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer-related deaths
worldwide. HCC initiation, progression, and therapy failure are all influenced by various …

[HTML][HTML] Functional roles of chemokine receptor CCR2 and its ligands in liver disease

S She, L Ren, P Chen, M Wang, D Chen… - Frontiers in …, 2022 - frontiersin.org
Chemokines are a family of cytokines that orchestrate the migration and positioning of
immune cells within tissues and are critical for the function of the immune system. CCR2 …

[HTML][HTML] Distinct histopathological phenotypes of severe alcoholic hepatitis suggest different mechanisms driving liver injury and failure

J Ma, A Guillot, Z Yang, B Mackowiak… - The Journal of …, 2022 - Am Soc Clin Investig
Intrahepatic neutrophil infiltration has been implicated in severe alcoholic hepatitis (SAH)
pathogenesis; however, the mechanism underlying neutrophil-induced injury in SAH …

[HTML][HTML] Role of neutrophils in the pathogenesis of nonalcoholic steatohepatitis

S Hwang, H Yun, S Moon, YE Cho… - Frontiers in endocrinology, 2021 - frontiersin.org
Nonalcoholic fatty liver disease (NAFLD) includes a spectrum of liver disorders, from fatty
liver to nonalcoholic steatohepatitis (NASH), cirrhosis, and hepatocellular carcinoma …

[HTML][HTML] Circular RNA circBCBM1 promotes breast cancer brain metastasis by modulating miR-125a/BRD4 axis

B Fu, W Liu, C Zhu, P Li, L Wang, L Pan… - … journal of biological …, 2021 - ncbi.nlm.nih.gov
Circular RNAs (circRNAs) play critical roles in tumorigenesis and the progression of various
cancers. We previously identified a novel upregulated circRNA, circBCBM1 …