Abstract Purpose of Review This review will explore the latest in advanced imaging
techniques, with a focus on the complementary nature of multiparametric, multimodality …

Measurements of early tumor responses to therapy have been shown, in some cases, to
predict treatment outcome. We show in lymphoma-bearing mice injected intravenously with …

Eighty percent of all malignant primary brain tumors diagnosed in the United States are
gliomas. 1 The current treatment paradigm for high-grade gliomas (grades III and IV) …

The structural heterogeneity of tumor tissue can be probed by diffusion MRI (dMRI) in terms
of the variance of apparent diffusivities within a voxel. However, the link between the …

Carcinogenesis involves the chemical and structural alteration of biomolecules in cells.
Aberrant methylation of DNA is a well-known carcinogenic mechanism and a common …

Imaging techniques are important for accurate diagnosis and follow-up of patients with
gliomas. T1-weighted MRI, with or without gadolinium, is the gold standard method …

An imaging biomarker that would provide for an early quantitative metric of clinical treatment
response in cancer patients would provide for a paradigm shift in cancer care. Currently …

The MRI community is using quantitative mapping techniques to complement qualitative
imaging. For quantitative imaging to reach its full potential, it is necessary to analyze …

Tumour responses to treatment are still largely assessed from imaging measurements of
reductions in tumour size. However, this can take several weeks to become manifest and in …

Diffusion-weighted magnetic resonance imaging (DWI) provides functional information and
can be used for the detection and characterization of pathologic processes, including …