Retinoic acid (RA), the major bioactive metabolite of retinol or vitamin A, induces a spectrum
of pleiotropic effects in cell growth and differentiation that are relevant for embryonic …

Over the past 20 years, immunophenotyping by flow cytometry has become an essential
laboratory tool in the diagnosis and classification of several hematologic malignancies. The …

The expression of CD56 antigen in acute promyelocytic leukemia (APL) blasts has been
associated with short remission duration and extramedullary relapse. We investigated the …

The clinical indications for diagnostic flow cytometry studies are an evolving consensus, as
the knowledge of antigenic definition of hematolymphoid malignancies and the prognostic …

Flow Cytometry of Hematological Malignancies Flow cytometric analysis is often integral to
the swift and accurate diagnosis of leukemias and lymphomas of the blood, bone marrow …

Expression of CD 56 has recently been introduced as one of the adverse prognostic factors
in acute promyelocytic leukemia (APL). However, the clinical significance of CD 56 antigen …

Acute promyelocytic leukemia (APL) is a rare leukemia characterized by the balanced
reciprocal translocation between the promyelocytic leukemia gene on chromosome 15 and …

Acute myeloid leukemia may manifest as myeloid sarcoma in a variety of extramedullary
(EM) tissues at diagnosis or at relapse. Although EM relapse after allogeneic hematopoietic …

This third edition is the product of the author's 25 years of experience with flow cytometry;
although it covers the wide spectrum of hematopoietic tumors, the focus remains on most …

Purpose Extensive studies have investigated the prognostic value of CD56 for patients with
acute myeloid leukemia (AML), but the results remained inconclusive. The aim of this meta …