Recent progress in Lyme disease and remaining challenges
Lyme disease (also known as Lyme borreliosis) is the most common vector-borne disease in
the United States with an estimated 476,000 cases per year. While historically, the long-term …
the United States with an estimated 476,000 cases per year. While historically, the long-term …
Eliciting B cell immunity against infectious diseases using nanovaccines
A Singh - Nature nanotechnology, 2021 - nature.com
Infectious diseases, including the coronavirus disease 2019 (COVID-19) pandemic that has
brought the world to a standstill, are emerging at an unprecedented rate with a substantial …
brought the world to a standstill, are emerging at an unprecedented rate with a substantial …
A SARS-CoV-2 ferritin nanoparticle vaccine elicits protective immune responses in nonhuman primates
MG Joyce, HAD King, I Elakhal-Naouar… - Science translational …, 2021 - science.org
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants
stresses the continued need for next-generation vaccines that confer broad protection …
stresses the continued need for next-generation vaccines that confer broad protection …
A single immunization with spike-functionalized ferritin vaccines elicits neutralizing antibody responses against SARS-CoV-2 in mice
The development of a safe and effective SARS-CoV-2 vaccine is a public health priority. We
designed subunit vaccine candidates using self-assembling ferritin nanoparticles displaying …
designed subunit vaccine candidates using self-assembling ferritin nanoparticles displaying …
[HTML][HTML] Emerging vaccine nanotechnology: from defense against infection to sniping cancer
Looking retrospectively at the development of humanity, vaccination is an unprecedented
medical landmark that saves lives by harnessing the human immune system. During the …
medical landmark that saves lives by harnessing the human immune system. During the …
Ferritin–a multifaceted protein scaffold for biotherapeutics
The ferritin nanocage is an endogenous protein that exists in almost all mammals. Its hollow
spherical structure that naturally stores iron ions has been diversely exploited by …
spherical structure that naturally stores iron ions has been diversely exploited by …
Functionalizing ferritin nanoparticles for vaccine development
In the last decade, the interest in ferritin-based vaccines has been increasing due to their
safety and immunogenicity. Candidates against a wide range of pathogens are now on …
safety and immunogenicity. Candidates against a wide range of pathogens are now on …
A bivalent Epstein-Barr virus vaccine induces neutralizing antibodies that block infection and confer immunity in humanized mice
CJ Wei, W Bu, LA Nguyen, JD Batchelor… - Science translational …, 2022 - science.org
Epstein-Barr virus (EBV) is the major cause of infectious mononucleosis and is associated
with several human cancers and, more recently, multiple sclerosis. Despite its prevalence …
with several human cancers and, more recently, multiple sclerosis. Despite its prevalence …
Biological nanoparticles in vaccine development
SM Curley, D Putnam - Frontiers in Bioengineering and …, 2022 - frontiersin.org
Vaccines represent one of the most successful public health initiatives worldwide. However,
despite the vast number of highly effective vaccines, some infectious diseases still do not …
despite the vast number of highly effective vaccines, some infectious diseases still do not …
CD4 T cell epitope abundance in ferritin core potentiates responses to hemagglutinin nanoparticle vaccines
Nanoparticle vaccines based on H. pylori ferritin are increasingly used as a vaccine platform
for many pathogens, including RSV, influenza, and SARS-CoV-2. They have been found to …
for many pathogens, including RSV, influenza, and SARS-CoV-2. They have been found to …