Vascular smooth muscle cells (VSMCs) are key participants in both early and late-stage
atherosclerosis. VSMCs invade the early atherosclerotic lesion from the media, expanding …

Atherosclerosis, characterized by lipid‐rich plaques in the arterial wall, is an age‐related
disorder and a leading cause of mortality worldwide. However, the specific mechanisms …

Hematopoietic stem cells (HSCs) residing in the bone marrow (BM) accumulate during
aging but are functionally impaired. However, the role of HSC-intrinsic and-extrinsic aging …

Laurent et al Early, Normal, and Supernormal Vascular Aging 219 normally defined by the
absence of variables linked to the metabolic syndrome. 21, 22 An alternative way to define …

Inflammation is a hallmark and potent driver of pathological vascular remodelling in
atherosclerosis. However, current anti-inflammatory therapeutic strategies have shown …

Objective: Vascular smooth muscle cells (SMCs) dedifferentiate and initiate expression of
macrophage markers with cholesterol exposure. This phenotypic switching is dependent on …

Abstract Aims Hutchinson-Gilford progeria syndrome (HGPS) is an accelerated ageing
syndrome associated with premature vascular disease and death due to heart attack and …

Atherosclerosis is an age-related disorder associated with long-term exposure to
cardiovascular risk factors. The asymptomatic progression of atherosclerotic plaques leads …

Model organisms have provided fundamental evidence that aging can be delayed and
longevity extended. These findings gave rise to a new era in aging research aimed at …

Atherosclerosis is the underlying cause for cardiovascular disease. Current
pharmacotherapies are limited by the inadequate targeting and insufficient treatment …