The vascular endothelial growth factor (VEGF) family members, VEGF-A, placenta growth
factor (PlGF), and to a lesser extent VEGF-B, play an essential role in tumor-associated …

Cell adhesion to the extracellular matrix has important roles in tissue integrity and human
health. Integrins are heterodimeric cell surface receptors that are composed by two non …

Blindness affects 60 million people worldwide. The leading causes of irreversible blindness
include age-related macular degeneration, retinal vascular diseases and glaucoma. The …

The vascular endothelial growth factor receptor-1 (VEGFR-1) is a tyrosine kinase receptor
for VEGF-A, VEGF-B, and placental growth factor (PlGF) ligands that is expressed in …

Normal tissue function requires adequate supply of oxygen through blood vessels.
Understanding how blood vessels form is a challenging objective because angiogenesis is …

Vascular endothelial growth factors (VEGFs) regulate blood and lymphatic vessel
development and homeostasis but also have profound effects on neural cells. VEGFs are …

Integrins are transmembrane heterodimeric proteins sensing the cell microenvironment and
modulating numerous signalling pathways. Changes in integrin expression between normal …

Background Angiogenesis is the process by which new blood vessels arise from pre-
existing ones. Fibroblast growth factor-2 (FGF-2), a leading member of the FGF family of …

Angiogenesis, the formation of new blood vessels from preexisting vasculature, contributes
to the pathogenesis of many disorders, including ischemic diseases and cancer. Integrins …

Integrins are a class of transmembrane receptors that are involved in a wide range of
biological functions. Dysregulation of integrins has been implicated in many pathological …