This article is part of a Special Issue “Neuroendocrine-Immune Axis in Health and Disease.”
Upregulation of indoleamine 2, 3-dioxygenase (IDO) by proinflammatory cytokines has been …

Inflammation and depression are closely inter-related; inflammation induces symptoms of
depression and, conversely, depressed mood and stress favor an inflammatory phenotype …

Inflammation and oxidative stress are involved in the pathophysiology of anxiety and
depression. Esculetin (ESC), a coumarin derived potent antioxidant, also possessing anti …

Neuroinflammation is implicated in impairments in neuronal function and cognition that arise
with aging, trauma, and/or disease. Therefore, understanding the underlying basis of the …

Among all major organs, the brain is one of the most susceptible to the inexorable effects of
aging. Throughout the last decades, several studies in human cohorts and animal models …

Although it is known that immune system activation can impair cognition, no study to date
has linked cognitive deficits during acute neuroinflammation to dysregulation of task …

Numerous studies have demonstrated that inflammation, oxidative stress and altered level of
neurotrophins are involved in the pathogenesis of depressive illness. Mangiferin, a C …

Lipopolysaccharide (LPS) administration is a well-established model to assess afferent
immune-to-brain communication and behavioral aspects of inflammation. Nevertheless, only …

Oxidative stress is a well-known risk factor for the development of anxiety and depression
disorders. Curcumin, a natural compound, is an antioxidant with well-known neuroprotective …

Anxiety disorders (AnxDs) are highly prevalent throughout the lifespan, with detrimental
effects on daily‐life functioning, somatic health, and quality of life. An emerging perspective …