The biologically relevant coordination chemistry of iron and nitric oxide: electronic structure and reactivity
Nitric oxide (NO) is an important signaling molecule that is involved in a wide range of
physiological and pathological events in biology. Metal coordination chemistry, especially …
physiological and pathological events in biology. Metal coordination chemistry, especially …
[HTML][HTML] Oxidative stress–Complex pathological issues concerning the hallmark of cardiovascular and metabolic disorders
Oxidative stress is a complex biological process characterized by the excessive production
of reactive oxygen species (ROS) that act as destroyers of the REDOX balance in the body …
of reactive oxygen species (ROS) that act as destroyers of the REDOX balance in the body …
Sources of vascular nitric oxide and reactive oxygen species and their regulation
J Tejero, S Shiva, MT Gladwin - Physiological reviews, 2019 - journals.physiology.org
Nitric oxide (NO) is a small free radical with critical signaling roles in physiology and
pathophysiology. The generation of sufficient NO levels to regulate the resistance of the …
pathophysiology. The generation of sufficient NO levels to regulate the resistance of the …
[HTML][HTML] Endothelial nitric oxide synthase (eNOS) and the cardiovascular system: in physiology and in disease states
N Tran, T Garcia, M Aniqa, S Ali, A Ally… - American journal of …, 2022 - ncbi.nlm.nih.gov
Endothelial nitric oxide synthase (eNOS) plays a critical role in regulating and maintaining a
healthy cardiovascular system. The importance of eNOS can be emphasized from the …
healthy cardiovascular system. The importance of eNOS can be emphasized from the …
Targeting vascular (endothelial) dysfunction
A Daiber, S Steven, A Weber… - British journal of …, 2017 - Wiley Online Library
Cardiovascular diseases are major contributors to global deaths and disability‐adjusted life
years, with hypertension a significant risk factor for all causes of death. The endothelium that …
years, with hypertension a significant risk factor for all causes of death. The endothelium that …
New therapeutic implications of endothelial nitric oxide synthase (eNOS) function/dysfunction in cardiovascular disease
The Global Burden of Disease Study identified cardiovascular risk factors as leading causes
of global deaths and life years lost. Endothelial dysfunction represents a pathomechanism …
of global deaths and life years lost. Endothelial dysfunction represents a pathomechanism …
[PDF][PDF] Single‐cell transcriptomic analysis reveals a hepatic stellate cell–activation roadmap and myofibroblast origin during liver fibrosis in mice
Background and Aims HSCs and portal fibroblasts (PFs) are the major sources of collagen‐
producing myofibroblasts during liver fibrosis, depending on different etiologies. However …
producing myofibroblasts during liver fibrosis, depending on different etiologies. However …
Interaction of risk factors, comorbidities, and comedications with ischemia/reperfusion injury and cardioprotection by preconditioning, postconditioning, and remote …
P Ferdinandy, DJ Hausenloy, G Heusch… - Pharmacological …, 2014 - ASPET
Pre-, post-, and remote conditioning of the myocardium are well described adaptive
responses that markedly enhance the ability of the heart to withstand a prolonged …
responses that markedly enhance the ability of the heart to withstand a prolonged …
Drosophila as a Genetic Model for Hematopoiesis
U Banerjee, JR Girard, LM Goins, CM Spratford - Genetics, 2019 - academic.oup.com
In this FlyBook chapter, we present a survey of the current literature on the development of
the hematopoietic system in Drosophila. The Drosophila blood system consists entirely of …
the hematopoietic system in Drosophila. The Drosophila blood system consists entirely of …
Effect of praliciguat on peak rate of oxygen consumption in patients with heart failure with preserved ejection fraction: the CAPACITY HFpEF randomized clinical trial
Importance Heart failure with preserved ejection fraction (HFpEF) is often characterized by
nitric oxide deficiency. Objective To evaluate the efficacy and adverse effects of praliciguat …
nitric oxide deficiency. Objective To evaluate the efficacy and adverse effects of praliciguat …