The biologically relevant coordination chemistry of iron and nitric oxide: electronic structure and reactivity

N Lehnert, E Kim, HT Dong, JB Harland… - Chemical …, 2021 - ACS Publications
Nitric oxide (NO) is an important signaling molecule that is involved in a wide range of
physiological and pathological events in biology. Metal coordination chemistry, especially …

[HTML][HTML] Oxidative stress–Complex pathological issues concerning the hallmark of cardiovascular and metabolic disorders

D Rotariu, EE Babes, DM Tit, M Moisi, C Bustea… - Biomedicine & …, 2022 - Elsevier
Oxidative stress is a complex biological process characterized by the excessive production
of reactive oxygen species (ROS) that act as destroyers of the REDOX balance in the body …

Sources of vascular nitric oxide and reactive oxygen species and their regulation

J Tejero, S Shiva, MT Gladwin - Physiological reviews, 2019 - journals.physiology.org
Nitric oxide (NO) is a small free radical with critical signaling roles in physiology and
pathophysiology. The generation of sufficient NO levels to regulate the resistance of the …

[HTML][HTML] Endothelial nitric oxide synthase (eNOS) and the cardiovascular system: in physiology and in disease states

N Tran, T Garcia, M Aniqa, S Ali, A Ally… - American journal of …, 2022 - ncbi.nlm.nih.gov
Endothelial nitric oxide synthase (eNOS) plays a critical role in regulating and maintaining a
healthy cardiovascular system. The importance of eNOS can be emphasized from the …

Targeting vascular (endothelial) dysfunction

A Daiber, S Steven, A Weber… - British journal of …, 2017 - Wiley Online Library
Cardiovascular diseases are major contributors to global deaths and disability‐adjusted life
years, with hypertension a significant risk factor for all causes of death. The endothelium that …

New therapeutic implications of endothelial nitric oxide synthase (eNOS) function/dysfunction in cardiovascular disease

A Daiber, N Xia, S Steven, M Oelze, A Hanf… - International journal of …, 2019 - mdpi.com
The Global Burden of Disease Study identified cardiovascular risk factors as leading causes
of global deaths and life years lost. Endothelial dysfunction represents a pathomechanism …

[PDF][PDF] Single‐cell transcriptomic analysis reveals a hepatic stellate cell–activation roadmap and myofibroblast origin during liver fibrosis in mice

WU Yang, H He, T Wang, N Su, F Zhang, K Jiang… - …, 2021 - Wiley Online Library
Background and Aims HSCs and portal fibroblasts (PFs) are the major sources of collagen‐
producing myofibroblasts during liver fibrosis, depending on different etiologies. However …

Interaction of risk factors, comorbidities, and comedications with ischemia/reperfusion injury and cardioprotection by preconditioning, postconditioning, and remote …

P Ferdinandy, DJ Hausenloy, G Heusch… - Pharmacological …, 2014 - ASPET
Pre-, post-, and remote conditioning of the myocardium are well described adaptive
responses that markedly enhance the ability of the heart to withstand a prolonged …

Drosophila as a Genetic Model for Hematopoiesis

U Banerjee, JR Girard, LM Goins, CM Spratford - Genetics, 2019 - academic.oup.com
In this FlyBook chapter, we present a survey of the current literature on the development of
the hematopoietic system in Drosophila. The Drosophila blood system consists entirely of …

Effect of praliciguat on peak rate of oxygen consumption in patients with heart failure with preserved ejection fraction: the CAPACITY HFpEF randomized clinical trial

JE Udelson, GD Lewis, SJ Shah, MR Zile, MM Redfield… - Jama, 2020 - jamanetwork.com
Importance Heart failure with preserved ejection fraction (HFpEF) is often characterized by
nitric oxide deficiency. Objective To evaluate the efficacy and adverse effects of praliciguat …