[HTML][HTML] Flavohaemoglobin: The pre-eminent nitric oxide–detoxifying machine of microorganisms

RK Poole - F1000Research, 2020 - ncbi.nlm.nih.gov
Flavohaemoglobins were first described in yeast as early as the 1970s but their functions
were unclear. The surge in interest in nitric oxide biology and both serendipitous and …

[HTML][HTML] Giardia duodenalis: Flavohemoglobin is involved in drug biotransformation and resistance to albendazole

EO Pech-Santiago, R Argüello-García… - PLoS …, 2022 - journals.plos.org
Giardia duodenalis causes giardiasis, a major diarrheal disease in humans worldwide
whose treatment relies mainly on metronidazole (MTZ) and albendazole (ABZ). The …

[HTML][HTML] Assessment of Drug Activities against Giardia Using Hyperspectral Raman Microscopy

FS Manciu, J Guerrero, BC Pence, LV Martinez Lopez… - Pathogens, 2024 - mdpi.com
This study demonstrates the capability of Raman microscopy for detecting structural
differences in Giardia cells exposed to different drugs and incubation times. While …

[HTML][HTML] Catalytic Differences between Flavohemoglobins of Giardia intestinalis and E. coli

S Hill, I Decorso, N Nezamololama, Z Babaei… - Pathogens, 2024 - mdpi.com
The sole known heme enzyme of the parasitic protist Giardia intestinalis is a
flavohemoglobin (gFlHb) that acts as a nitric oxide dioxygenase (NOD) and protects the …

Nitric oxide in parasitic infections: a friend or foe?

M Omar, HO Abdelal - Journal of Parasitic Diseases, 2022 - Springer
The complex interaction between the host and the parasite remains a puzzling question.
Control of parasitic infections requires an efficient immune response that must be balanced …