The thymus is the primary immune organ responsible for generating self‐tolerant and
immunocompetent T cells. However, the thymus gradually involutes during early life …

Dendritic cells (DCs) are potent antigen-presenting cells (APCs) that are essential in
mediating the body's natural and adaptive immune responses. The body can regulate the …

Abstract Aflatoxin B1 (AFB1) is a common contaminant in many foodstuffs and is considered
a public health concern worldwide due to its hepatotoxicity caused by lipid metabolism …

Thymic epithelial cells (TECs) are essential for the production of self-tolerant T cells. The
newly identified thymic tuft cells are regulated by Pou2f3 and represent important elements …

Thymic epithelial cells (TECs) are important for T cell development and immune tolerance
establishment. Although comprehensive molecular regulation of TEC development has …

Myeloid hematopoiesis is a finely controlled consecutive developmental process, which is
essential to maintain peripheral innate immune homeostasis. Herein, we found that Rictor …

T lymphocytes are pivotal in adaptive immunity. The role of the trafficking protein particle
complex (TRAPPC) in regulating T‐cell development and homeostasis is unknown. Using …

The generation of mature T cells and establishment of central tolerance is predominantly
orchestrated by thymic epithelial cells (TECs). Proprotein convertases are responsible for …

Thymic epithelial cells (TECs) critically participate in T cell maturation and selection for the
establishment of immunity to foreign antigens and immune tolerance to self-antigens of T …

Heat shock protein-90 (Hsp90) is an ATP-dependent molecular chaperone that is tightly
regulated by a group of proteins termed co-chaperones. This chaperone system is essential …