Dysregulated growth hormone (GH) hypersecretion is usually caused by a GH-secreting
pituitary adenoma and leads to acromegaly—a disorder of disproportionate skeletal, tissue …

The pituitary gland is a central endocrine organ regulating basic physiological functions,
including growth, the stress response, reproduction, metabolic homeostasis, and lactation …

The Otx2 gene encodes a transcription factor essential for the normal development of brain,
cerebellum, pineal gland, and eye. In the retina, Otx2 has essential functions from early …

The pituitary gland represents the endocrine core, governing the body's hormonal
landscape by adapting its cellular composition to changing demands. It is assumed that …

Acromegaly is a rare, chronic, progressive disease characterized by an excess secretion of
growth hormone (GH) and increased circulating insulin-like growth factor 1 (IGF-1) …

Abstract Context: The LHX4 LIM-homeodomain transcription factor has essential roles in
pituitary gland and nervous system development. Heterozygous mutations in LHX4 are …

Context: Although recent studies have suggested a positive role of OTX2 in pituitary as well
as ocular development and function, detailed pituitary phenotypes in OTX2 mutations and …

The use of zebrafish (Danio rerio) in scientific research is growing rapidly. It initially became
popular as a model of vertebrate development because zebrafish embryos develop rapidly …

We identified four unrelated patients (three female, one male) aged 20 to 30 years with
hypomyelination, pituitary hypogonadotropic hypogonadism, and hypodontia. Electron …

Schilter KF, Schneider A, Bardakjian T, Soucy J‐F, Tyler RC, Reis LM, Semina EV. OTX2
microphthalmia syndrome: four novel mutations and delineation of a phenotype. The OTX2 …