Organophosphorus compounds have been utilized as pesticides for almost five decades.
They continue to be used as insecticides, helminthicides, ascaricides, nematocides, and to a …

Chronic exposure to agonist (or conditions that increase the synaptic concentration of the
natural transmitter, such as blockade of inactivation mechanisms) results in a …

Three radioligands have been commonly used to label putative nicotinic cholinoceptors in
the mammalian central nervous system: the agonists [3H] nicotine and [3H] acetylcholine …

In a postmortem study of nicotinic receptors in human brain, cigarette smoking was found to
be associated with increased (−)[3H] nicotine binding to membranes prepared from gyrus …

Cholinesterases are measured to assess exposures to or effects of organophosphorus
esters and carbamates. Plasma butyrylcholinesterase is usually most sensitive to inhibitors …

Chlorpyrifos (diethyl 3, 5, 6trichloro2pyridyl phosphorothionate) is a broadspectrum
organophosphorus (OP) insecticide. Anticipated increases in the already extensive use of …

The in vivo regulation of [3H] acetylcholine ([3H] ACh) recognition sites on nicotinic
receptors in ratbrain was examined by administering drugs that increase stimulation of …

Putative nicotine receptors in the human cerebral cortex were characterized with l[3H]
nicotine. l[3H] Nicotine binding was enhanced by the addition of Ca2+ and abolished in the …

The brain is a well-organized, yet highly complex, organ in the mammalian system. Most
investigators use the whole brain, instead of a selected brain region (s), for biochemical …

Acute exposure to the organophosphate pesticide chlorpyrifos (CPF) on gestation day 12
(GD12, 200 mg/kg/ml, SC) causes extensive neurochemical changes in maternal brain but …