T cell activation requires extracellular stimulatory signals that are mainly mediated by T cell
receptor (TCR) complexes. The TCR recognizes antigens on major histocompatibility …

GATA transcriptional factors are zinc finger DNA binding proteins that regulate transcription
during development and cell differentiation. The 3 important GATA transcription factors …

Neutrophil gelatinase-associated lipocalin (NGAL) is a 25-kDa lipocalin first identified as a
protein stored in specific granules of the human neutrophil. The protein is believed to bind …

The zinc finger transcription factor GATA4 has been implicated in heart development based
on its early expression in precardiogenic splanchnic mesoderm and its ability to activate the …

Previous studies have suggested that the GATA4 transcription factor plays an important role
in regulating mammalian cardiac development. In the studies described in this report we …

Six GATA transcription factors have been identified in vertebrates, each of which contains a
highly conserved DNA binding domain consisting of two zinc fingers of the motif Cys-X2-Cys …

Many advances in our understanding of the molecules that regulate the development,
differentiation and function of T cells have been made over the past few years. One …

The development of mature blood cells of distinct lineages, from the hematopoietic stem
cells (HSCs), involves a progressive restriction of differentiation potential and the …

GATA–3 is one member of a growing family of related transcription factors which share a
strongly conserved expression pattern in all vertebrate organisms. In order to elucidate …

GATA factors interact with simple DNA motifs (WGATAR) to regulate critical processes,
including hematopoiesis, but very few WGATAR motifs are occupied in genomes. Given the …