Genome-wide association studies and functional genomics studies have linked specific cell
types, genes, and pathways to Alzheimer's disease (AD) risk. In particular, AD risk alleles …

The mammalian brain is a complex organ comprising neurons, glia, and more than 1× 1014
synapses. Neurons are a heterogeneous group of electrically active cells, which form the …

A fundamental breakthrough in neurobiology has been the formulation of the neuron
doctrine by Santiago Ramón y Cajal, which stated that the nervous system is composed of …

Microglia are critical regulators of brain development that engulf synaptic proteins during
postnatal synapse remodeling. However, the mechanisms through which microglia sense …

Major depressive disorder (MDD) is a debilitating neuropsychological disorder, which has
caused serious health and socio-economic burdens worldwide. A growing body of evidence …

Microglia are the tissue-resident macrophage population of the brain, specialized in
supporting the CNS environment and protecting it from endogenous and exogenous insults …

Sound stimulus is encoded in mice by three molecularly and physiologically diverse
subtypes of sensory neurons, called Ia, Ib, and Ic spiral ganglion neurons (SGNs). Here, we …

The innate immune landscape of the central nervous system (CNS), including the brain and
the retina, consists of different myeloid cell populations with distinct tasks to fulfill. Whereas …

Mammalian infants depend on parental care for survival, with numerous consequences for
their behavioral development. We investigated the epigenetic and neurodevelopmental …

Early life adversity impairs normal hippocampal function and connectivity in various
mammalian species, including humans and rodents. According to the 'cumulative model'the …