The transition from normal to chronic pain is believed to involve alterations in several brain
areas that participate in the perception of pain. These plastic changes are then responsible …

In addition to being a key component of the autonomic nervous system, acetylcholine acts as
a prominent neurotransmitter and neuromodulator upon release from key groups of …

Chemotherapy-induced peripheral neuropathy (CIPN) is a common, debilitating, and dose-
limiting side effect of many chemotherapy regimens yet has limited treatments due to …

Chemotherapy-induced peripheral neuropathy (CIPN) is a severe adverse effect observed
in most patients treated with neurotoxic anti-cancer drugs. Currently, there are no …

Introduction Cholinergic dysfunction, demonstrated in the late 1970s and early 1980s, led to
the introduction of acetylcholinesterase inhibitors (AChEIs) in 1993 (Tacrine) to enhance …

Nociception is the neuronal process of encoding noxious stimuli and could be modulated at
peripheral, spinal, brainstem, and cortical levels. At cortical levels, several areas including …

Neuropathic pain is a major worldwide health problem. Although central sensitization has
been reported in well-established neuropathic conditions, information on the acute brain …

Neuropathic pain is difficult to cure and is often accompanied by emotional and
psychological changes. Exploring the mechanisms underlying neuropathic pain will help to …

In chronic pain, the medial prefrontal cortex (mPFC) is deactivated and mPFC-dependent
tasks such as attention and working memory are impaired. We investigated the mechanisms …

Early life pain (ELP) experience alters adult pain behavior and increases injury-induced
pain hypersensitivity, but the effect of ELP on adult functional brain connectivity is not known …