The interruption of malaria transmission worldwide is one of the greatest challenges for
international health and development communities. The current expert view suggests that …

Malaria remains a serious worldwide health danger and massive economic trouble to
disease-endemic nations. Presently, 250 million of malarial cases are expected worldwide …

The huge burden of malaria in developing countries urgently demands the development of
novel approaches to fight this deadly disease. Although engineered symbiotic bacteria have …

Recent reports of increased tolerance to artemisinin derivatives—the most recently adopted
class of antimalarials—have prompted a need for new treatments. The spirotetrahydro-β …

Achieving the goal of malaria elimination will depend on targeting Plasmodium pathways
essential across all life stages. Here we identify a lipid kinase, phosphatidylinositol-4-OH …

Artemisinin combination therapies are the first-line treatments for uncomplicated
Plasmodium falciparum malaria in most malaria-endemic countries. Recently, partial …

Background An effective vaccine for malaria is urgently needed. Naturally acquired immunity
to malaria develops slowly, and induction of protection in humans can be achieved …

Malaria, caused by parasites of the genus Plasmodium, is one of the leading infectious
diseases in many tropical regions, including Nigeria, a West African country where …

Background Malaria remains a disease of devastating global impact, killing more than
800,000 people every year—the vast majority being children under the age of 5. While …

Clinical manifestations of Plasmodium falciparum infection are induced by the asexual
stages of the parasite that develop inside red blood cells (RBCs). Because splenic …