Drug-resistant epilepsy: definition, pathophysiology, and management

B Mesraoua, F Brigo, S Lattanzi, B Abou-Khalil… - Journal of the …, 2023 - Elsevier
There are currently> 51 million people with epilepsy (PWE) in the world and every year> 4.9
million people develop new-onset epilepsy. The cornerstone of treatment in PWE is drug …

Prevention of epileptogenesis–are we there yet?

M Koepp, E Trinka, W Löscher… - Current Opinion in …, 2024 - journals.lww.com
No disease-modifying or preventive treatments exist for epilepsy, and their development
remains a major unmet need.. We have entered though the era of change in the treatment of …

[HTML][HTML] Neutrophil-to-lymphocyte ratio predicts early neurological deterioration after endovascular treatment in patients with ischemic stroke

S Lattanzi, D Norata, S Broggi, S Meletti, M Świtońska… - Life, 2022 - mdpi.com
The worsening of neurological status that occurs early after acute ischemic stroke (AIS)
remains a serious issue, and the inflammatory response plays a key role in stroke …

Revisiting the concept of drug‐resistant epilepsy: a TASK1 report of the ILAE/AES Joint Translational Task Force

S Auvin, AS Galanopoulou, SL Moshé, H Potschka… - …, 2023 - Wiley Online Library
Despite progress in the development of anti‐seizure medications (ASMs), one third of
people with epilepsy have drug‐resistant epilepsy (DRE). The working definition of DRE …

[HTML][HTML] Response to subsequent antiseizure medications after first antiseizure medication failure in newly diagnosed epilepsy

H Hersi, JT Saarinen, J Raitanen, J Peltola - Frontiers in Neurology, 2022 - frontiersin.org
Objective There is a lack of studies using the International League Against Epilepsy (ILAE)
recommendation to define drug-resistant epilepsy (DRE). This study evaluated the seizure …

Antiepileptogenesis after stroke—trials and tribulations: Methodological challenges and recruitment results of a Phase II study with eslicarbazepine acetate

MJ Koepp, E Trinka, YH Mah, C Bentes… - Epilepsia …, 2023 - Wiley Online Library
There is currently no evidence to support the use of antiseizure medications to prevent
unprovoked seizures following stroke. Experimental animal models suggested a potential …

Futile recanalization is associated with increased risk of post-stroke epilepsy

S Lattanzi, C Cuccurullo, N Orlandi, G Borzì… - Journal of the …, 2024 - Elsevier
Background Endovascular treatment (EVT) is the standard of care of ischaemic stroke due to
occlusion of large vessels. Although EVT can significantly improve short-and long-term …

[HTML][HTML] Individualized prediction of drug resistance in people with post-stroke epilepsy: a retrospective study

S Lattanzi, S Meletti, E Trinka, F Brigo… - Journal of Clinical …, 2023 - mdpi.com
Background: The study aimed to develop a model and build a nomogram to predict the
probability of drug resistance in people with post-stroke epilepsy (PSE). Methods: Subjects …

Proceedings of the “International Congress on Structural Epilepsy & Symptomatic Seizures”(STESS, Gothenburg, Sweden, 29–31 March 2023)

F Brigo, J Zelano, L Abraira, C Bentes, CT Ekdahl… - Epilepsy & Behavior, 2024 - Elsevier
In 2019, over 130 people from several countries travelled to Gothenburg, Sweden, for the
Seizures and Stroke Congress, the first international conference devoted to post-stroke …

[HTML][HTML] Diagnosis and treatment of poststroke epilepsy: where do we stand?

M Mauritz, KN Poppert, E Trinka… - Current Treatment Options …, 2023 - Springer
Abstract Purpose of Review Stroke is the most common cause of seizures and epilepsy in
older adults. This educational paper aims to give an update on current clinical aspects of …