Challenges in clinical development of mesenchymal stromal/stem cells: concise review

I Mastrolia, EM Foppiani, A Murgia… - Stem cells …, 2019 - academic.oup.com
Identified 50 years ago, mesenchymal stromal/stem cells (MSCs) immediately generated a
substantial interest among the scientific community because of their differentiation plasticity …

Concise review: mesenchymal stem cell-based drug delivery: the good, the bad, the ugly, and the promise

TEG Krueger, DLJ Thorek… - Stem cells …, 2018 - academic.oup.com
The development of mesenchymal stem cells (MSCs) as cell-based drug delivery vectors for
numerous clinical indications, including cancer, has significant promise. However, a …

Shrinkage-mediated imaging of entire organs and organisms using uDISCO

C Pan, R Cai, FP Quacquarelli, A Ghasemigharagoz… - Nature …, 2016 - nature.com
Recent tissue-clearing approaches have become important alternatives to standard
histology approaches. However, light scattering in thick tissues and the size restrictions on …

Mesenchymal stem cell‐based therapy for kidney disease: a review of clinical evidence

AJ Peired, A Sisti, P Romagnani - Stem cells international, 2016 - Wiley Online Library
Mesenchymal stem cells form a population of self‐renewing, multipotent cells that can be
isolated from several tissues. Multiple preclinical studies have demonstrated that the …

Mesenchymal stem cell therapy: A promising cell‐based therapy for treatment of myocardial infarction

AES Shafei, MA Ali, HG Ghanem… - The journal of gene …, 2017 - Wiley Online Library
For decades, mesenchymal stem (MSCs) cells have been used for cardiovascular diseases
as regenerative therapy. This review is an attempt to summarize the types of MSCs involved …

[HTML][HTML] Clinical potential of mesenchymal stem/stromal cell-derived extracellular vesicles

B Giebel, L Kordelas, V Börger - Stem cell investigation, 2017 - ncbi.nlm.nih.gov
Within the last two decades mesenchymal stem/stromal cells (MSCs) emerged after
hematopoietic stem cells as the second most investigated and applied somatic stem cell …

Mesenchymal stem cell immunomodulation: In pursuit of controlling COVID-19 related cytokine storm

N Song, H Wakimoto, F Rossignoli, D Bhere… - Stem Cells, 2021 - academic.oup.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has grown to be a global
public health crisis with no safe and effective treatments available yet. Recent findings …

Exosomal microRNAs derived from umbilical mesenchymal stem cells inhibit hepatitis C virus infection

X Qian, C Xu, S Fang, P Zhao, Y Wang… - Stem cells …, 2016 - academic.oup.com
Hepatitis C virus (HCV) is a significant global public health problem, causing more than
350,000 deaths every year. Although the development of direct-acting antivirals has …

[HTML][HTML] Exosome: a new player in translational nanomedicine

H Aheget, M Tristán-Manzano, L Mazini… - Journal of Clinical …, 2020 - mdpi.com
Exosomes are extracellular vesicles released by the vast majority of cell types both in vivo
and ex vivo, upon the fusion of multivesicular bodies (MVBs) with the cellular plasma …

Mesenchymal stem/stromal cells in regenerative medicine: past, present, and future

O Trohatou, MG Roubelakis - Cellular reprogramming, 2017 - liebertpub.com
Abstract The concept of Regenerative Medicine combined with Cell based Therapy and
Tissue Engineering represents the fourth pillar of healthcare and provides a promising …