P-glycoprotein (P-gp) is crucial in the active transport of various substrates with diverse
structures out of cells, resulting in poor intestinal permeation and limited bioavailability …

Oral administration has been the most common therapeutic regimen in various diseases
because of its high safety, convenience, lower costs, and high compliance of patients …

Uric acid is the final oxidation product of purine metabolism in humans. Xanthine
oxidoreductase (XOR) catalyzes oxidative hydroxylation of hypoxanthine to xanthine to uric …

Oral delivery via the gastrointestinal (GI) tract is the dominant route for drug administration.
Orally delivered liposomal carriers can enhance drug solubility and protect the encapsulated …

A major drawback of oral treatment of inflammatory bowel disease (IBD) is the non-specific
distribution of drugs during long-term treatment. Despite its effectiveness as an anti …

Oral administration of medication is the first option when patient compliance is considered.
However, many barriers face oral absorption of drugs that limit bioavailability in about 90 …

The treatment of cancer is still a major challenge. But tremendous progress in anticancer
drug discovery and development has occurred in the last few decades. However, this …

This paper reviews the work carried out on cyclodextrins during some thirty years at the
Institut Galien Paris-Sud, UMR CNRS 8612, Université Paris-Sud. It represents the normal …

A novel chitosan-based multifunctional nanoparticle (PY-CS-PLA) using cationic polylysine
(PL) polymer and L-cysteine has been developed and investigated for the oral delivery of …

In the rapidly expanding field of nanomedicine, liposomes have been considered as the
most successful drug carrier having various clinically approved products. However, their …