Oestrogens and their receptors contribute broadly to physiology and diseases. In
premenopausal women, endogenous oestrogens protect against cardiovascular, metabolic …

Estrogens mediate profound effects throughout the body and regulate physiological and
pathological processes in both women and men. The low prevalence of many diseases in …

Estrogens play a critical role in many aspects of physiology, particularly female reproductive
function, but also in pathophysiology, and are associated with protection from numerous …

Abstract Introduction Carcinoma-associated fibroblasts (CAFs) play a pivotal role in cancer
progression by contributing to invasion, metastasis and angiogenesis. Solid tumors possess …

The Notch signaling pathway acts in both physiological and pathological conditions,
including embryonic development and tumorigenesis. In cancer progression, diverse …

The G protein-coupled estrogen receptor (GPER) is a seven-transmembrane-domain
receptor that mediates non-genomic estrogen related signaling. After ligand activation …

Background Hypoxia plays a relevant role in tumor-related inflammation toward the
metastatic spread and cancer aggressiveness. The pro-inflammatory cytokine interleukin-1β …

Copper promotes tumor angiogenesis, nevertheless the mechanisms involved remain to be
fully understood. We have recently demonstrated that the G-protein estrogen receptor …

Endogenous estrogens are important regulators of cardiovascular homeostasis in
premenopausal women and delay the development of hypertension and coronary artery …

The recent discovery of the G protein-coupled estrogen receptor (GPER) presents new
challenges and opportunities for understanding the physiology, pathophysiology, and …